CONTINUATION PAGE: STA’ 7ITHIN MARGINS INDICATED 
Principal Investigator/Program Director (Last, first, middle ): . 

Crystal, RG (Continued) 
Publications 
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Yoshimura K, Nakamura H, Trapnell BC, Dalemans W, Pavirani A, Lecocq J-P, Crystal RG. The 
cystic fibrosis gene has a "housekeeping" type promoter and is expressed at low levels in cells of 
epithelial origin. J Biol Chem 1991; 266(14): 9140-9144. 
Fukayama M, Kanno T, Brody S, Kirby M, Crystal RG. Respiratory tract "organ specific gene therapy: 
transplantation of genetically modified T-lymphocytes directly to the respiratory epithelial lining fluid. J 
Biol Chem 1991; 266(27): 18339-18344. 
Yoshimura K, Nakamura H, Trapnell BC, Chu C-S, Dalemans W, Pavirani A, Lecocq J-P, Crystal RG. 
Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of nonepithelial 
origin. Nucl Acids Res 1991; 19: 5417-5423. 
Rosenfeld MA, Yoshimura K, Trapnell BC, Yoneyama K, Rosenthal ER, Dalemans W, Fukayama M, 
Bargon J, Stier LE, Stratford-Perricaudet LD, Perricaudet M, Guggino WB, Pavirani A, Lecocq J-P, 
Crystal RG. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to 
the airway epithelium. Cell 1992; 68: 143-155. 
Dalemans W, Barbry P, Champigny G, Jallat S, Dott K, Dreyer D, Crystal RG, Pavirani A, Lazdunski 
M, Lecocq J-P. Altered Cl-channel kinetics associated with the major(AF508) cystic fibrosis mutation 
Nature 1991; 354: 526-528. 
Bargon J, Trapnell BC, Chu C-S, Rosenthal ER, Yoshimura K, Guggino WB, Dalemans W, Pavirani A, 
Lecocq J-P, Crystal RG. Down-regulation of cystic fibrosis transmembrane conductance regulator gene 
expression by agents that modulate intracellular divalent cations. Molec Cell Biol. 1992; 12:4: 1872- 
1878. 
Lemarchand P, Jaffe HA, Danel C, Cid MC, Kleinman HK, Stratford-Perricaudet LD, Perricaudet M, 
Pavirani A, Lecocq J-P, Crystal RG. Adenovirus-mediated transfer of a recombinant human al- 
antitrypsin cDNA to human endothelial cells. Proc Natl Acad Science 1992; 89: 6482-6486. 
Yoshimura K, Rosenfeld MA, Nakamura H, Scherer EM, Parvirani A, Lecocq J-P, Crystal RG. 
Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung 
after in vivo intratracheal plasmid-mediated gene transfer. Nucl Acid Res. 1992; 20: 3233-3240. 
Chu CS, Trapnell BC, Curristin SM, Cutting GR, Crystal RG. Extensive post transcriptional deletion of 
the coding sequences for part of nucleotide-binding fold in respiratory epithelial mRNA transcripts of the 
cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical 
manifestations of cystic fibrosis. J Clin Invest. 1992; 90: 785-790. 
Bargon J, Trapnell BC, Yoshimura K, Dalemans W, Pavirani A, Lecocq J-P, Crystal, RG. Expression of 
the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C. J 
Biol Chem. 1992; 23: 16056-16060. 
Jaffe HA, Danel C, Longenecker G, Metzger M, Setoguchi Y, Rosenfeld MA, Gant TW, Thorgeirsson 
SS, Stratford-Perricaudet LD, Perricaudet M, Pavirani A, Lecocq J-P, Crystal RG. Hepatic gene 
therapy: replication deficient, recombinant adenovirus-mediated in vivo gene transfer and expression in 
normal rat liver. Nature Genetics. 1992; 1(3): 368-371. 
Chu C-S, Trapnell BC, Curristin S, Cutting GR, Crystal RG. Genetic basis for variable exon 9 skipping 
in cytic fibrosis transmembrane conductance regulator mRNA. Nature Genetics. Nature Genetics 1993; 
3: 151-156. 
14. Mastrangeli A, Danel C, Rosenfeld MA, Stratford-Perricaudet L, Perricaudet M, Pavirani A, Lecocq J- 
P, Crystal RG. Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated 
gene transfer. J Clin Invest. 1993; 91: 225-234. 
15. Yoshimura K, Rosenfeld MA, Seth P, Crystal RG. Adenovirus-mediated Augmentation of cell 
transfection with unmodified plasmid vectors. J Biol Chem. 1993; 268 (4): 2300-2303. 
16. Bajocchi G, Feldman SH, Crystal RG, Mastrangeli A. Direct ]n vivo transfer to ependymal cells in the 
central nervous system using replication deficient adenovirus vectors. Nature Genetics 1993; 3: 229-234. 
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Recombinant DNA Research, Volume 20 
