Protocol 
APPLIED IMMUNE SCIENCES, INC. 
5301 Patrick Henry Drive 
Santa Clara, CA 95054 
April 13, 1994 
BB-IND NUMBER: 
PROTOCOL NUMBER: 
AIS-1061-9406 
STUDY TITLE: 
Pilot Study of Autologous Human 
Interleukin-2 (IL-2) Gene Modified Tumor 
Cells In Patients with Refractory or Recurrent 
Metastatic Breast Cancer 
MEDICAL MONITOR: 
STUDY MONITOR: 
Annemarie Moseley, Ph.D., M.D. 
Vice President, Clinical Research 
Applied Immune Sciences, Inc. 
(408)980-5819 
Ann C. Neale, R.N., B.S.N. 
Clinical Program Manager 
Applied Immune Sciences, Inc. 
5301 Patrick Henry Drive 
Santa Clara, CA 95054 
(408)980-5844 
(408)980-5888 FAX 
STUDY: 
PRINCIPAL INVESTIGATOR 
H. Kim Lyerly, M.D. 
Duke University Medical Center 
Box 3551 
Durham, NC 27710 
Tel: (919) 681-8350 
Fax: (919) 681-7970 
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Recombinant DNA Research, Volume 20 
