FF 
Principal Investigator/Program Director (Last, first, middle): LYERLY. M.D.. HERBFRT KIM 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants listed on page 2. Begin with the Principal 
Investigator/Program Director. Photocopy this page for each person. 
CVs 
TOTE POi>l I ION III Lb 
Herbert Kim Lyerly, M.D. Assitant Professor 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
“DECREE - 
TEAR 
CONFERRED 
FIHujOfSIUDY 
University of California, Riverside 
BS 
1980 
Biomedical Sciences 
University of California, Los Angeles 
MD 
1983 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, 
experience, and honors. Include present membership on any Federal Government public advisory committee. List, in chronological order, 
the titles and complete references to all publications during the past three years and to representative earlier publications pertinent to this 
application. DO NOT EXCEED TWO PAGES. 
ASSISTANT PROFESSOR: 
DEPARTMENT OF PATHOLOGY 
DEPARTMENT OF SURGERY 
DUKE UNIVERSITY MEDICAL CTR 
1991 - PRESENT 
1990 - PRESENT 
POST-DOCTORAL FELLOW: 
DEPT. MICROBIOLOGY/IMMUNOLOGY 
(BRYAN R. CULLEN, PH.D.) 
DUKE UNIVERSITY MEDICAL CTR 
1990-1991 
RESIDENT IN SURGERY 
DEPARTMENT OF SURGERY 
DUKE UNIVERSITY MEDICAL CTR 
1987-1990 
POST-DOCTORAL FELLOW: 
DEPT. MICROBIOLOGY/IMMUNOLOGY 
(DANI P. BOLOGNESI, PH.D.) 
DUKE UNIVERSITY MEDICAL CTR 
1985 - 1987 
CONSULTANT: 
NIH STUDY SECTION MEMBER (AD HOC) 1988 
AIDS AND RELATED RESERACH GROUP 
NIH STUDY SECTION MEMBER (AD HOC) 1991 
AIDS AND CELLULAR/MOLECULAR VIROLOGY 
SCIENTIFIC ADVISORY COMMITTEE 1990 - PRESENT 
AMERICAN FOUNDATION FOR AIDS RESEARCH 
EDITORIAL BOARD: 
ANNALS OF SURGERY 
1991 - PRESENT 
PUBLICATIONS: A representative listing from a total of 1 15. 
1 . Yarchoan R, Klecker RW, Weinhold KJ, Markham PD, Lyerly HK, Durack DT, Gelmann 
E, Lehrman SN, Blum RM, Barry DW, Shearer GM, Fischl MA, Mitsuya H, Gallo RC, 
Colling JC, Bolognesi DP, Myers CE, Broder S: Administration of 3'-azido-3' 
deoxy thymidine, an inhibitor of HTLV-ITI/LAV replication, to patients with AIDS or 
AIDS -related complex. Lancet l(8481):575-80, 1986. 
2. Lyerly HK, Weinhold KJ, Cohen OJ, Bolognesi DP: Defects in T-cell function after 
infection with HTLV-UI/LAV. Surgical Forum 37:404, 1986. 
3. Lyerly HK, Cohen OJ, Weinhold KJ: Transmission of HIV by antigen presenting cells 
during T-cell activation: prevention by 3’-azido-3 '-deoxy thymidine. AIDS Research & 
Human Retroviruses, 3(l):87-94, 1987 Spring. 
4. Lyerly HK, Matthews TJ, Langlois AJ, Bolognesi DP, Weinhold KJ: Human T-cell 
lymphotropic virus IIIB glycoprotein (gpl20) bound to CD4 determinants on normal 
lymphocytes and expressed by infected cells serves as a target for immune attack. Proc Natl 
Acad Sci USA 84(13):4601-05, 1987 Jul. 
5 . Matthews TJ, Weinhold KJ, Lyerly HK, Langlois AJ, Wigzell H, Bolognesi DP: 
Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein 
gpl20 and the surface antigen CD4: role of carbohydrate in binding and cell fusion. Proc 
Natl Acad Sci USA 84(15):5424-8, 1987 Aug. 
6. Rusche JR, Lynn DL, Robert-Guroff M, Langlois AJ, Lyerly HK, Carson H, Krohn K, 
Ranki A, Gallo RC, Bolognesi DP, Putney SD, Matthews TJ: Humoral immune response 
to the entire human immunodeficiency virus envelope glycoprotein made in insect cells. 
Proc Natl Acad Sci USA 84(19):6924-8, 1987. 
7. Lyerly HK, Matthews TJ, Aheame PM, Langlois AJ, Bolognesi DP, Weinhold KJ: 
Augmentation of anti-HIV ADCC with Interleukin 2: Surgical Forum 38:425, 1987. j 
Recombinant DNA Research, Volume 20 
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