Protocol 
Retroviral-Mediated Transfer of the Iduronate-2-Sulfatase Gene 
Into Lymphocytes for Treatment of Mild Hunter Syndrome 
(Mucopolysaccharidosis Type II) 
Human Gene Therapy Protocol 
University of Minnesota Medical School 
Minneapolis, MN 
Date: 
July 20, 1994 
Principal Investigator: 
Chester B. Whitley, Ph.D., M.D. 
Associate Investigator: 
R Scott Mclvor, Ph.D. 
Collaborators: 
Susan A. Berry, M.D. 
Bruce R Blazar, M.D. 
John H. Kersey, M.D. 
Richard A. King, M.D., Ph.D. 
Anthony J. Faras, Ph.D. 
Richard E. Latchaw, M.D. 
Jeffrey J. McCullough, M.D. 
Norma K.C. Ramsay, M.D. 
Number of Subjects: 
4 (2 adults, 2 children) 
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Recombinant DNA Research, Volume 20 
