FF 
Principal Investigator/Program Director (Last, first, middle): Tsner. Jeffrey Mirhapl 
BIOGRAPHICAL SKETCH 
Give tne following information for the key personnel and consultants and collaborators. Begin with the pnncipal 
mvestigator/program director. Photocopy this page for each person. 
CVs 
AME 
,effrey M. Isner, 
POSITION TITLE Professor of Medicine and Pathology, Tuft 
University School of Medicine, Chief, Cardiovascular 
Research, St. Elizabeth's Medical Center, Boston, MA 
EDUCATION (Begin with baccalaureate or other initial professional education . such as nursing , and indude postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Tufts University School of Medicine 
Boston, MA 
M.D. 
1973 
Medicine 
University of Maryland 
College Park, Maryland 
B.S. 
1969 
Zoology 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment experience, and* 
honors. Key personnel include the pnncipal investigator and any other individuals who participate in the scientific development or execution of the project. 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contnbute in a substantive way to the scientific development or execution of the project Include present membership on 
any Federal Government public advisory committee. List in chronological order, the titles, all authors, and complete references to all publications dunng the 
past three years and to representative eartier publications pertinent to this application. If the list of publications in the last three years exceeds two pages, 
select the most pertinent publications. DO NOT EXCEED TWO PAGES. 
Professor of Medicine and Pathology, Tufts University School of Medicine, Boston, MA 
Chief, Cardiovascular Research, Sl Elizabeth's Hospital, Boston, MA 
Director, Tufts University School of Medicine Medical Student Clerkship: Vascular Medicine 
Adivsory Groups 
Peripheral Vascular Disease Committee, American College of Cardiology (Chairman 3/94-3/97) 
Research Policy Committee, American Heart Association, Massachusetts Affiliate (1991 -present). 
Cardiovascular A Study Section (NHLBI) (July 1, 1991-June 30, 1995) 
Editorial Board 
Circulation 
oumal of the American College of Cardiology 
>oumal of Vascular Medicine and Biology 
Trends in Cardiovascular Medicine (Executive Editor) 
Selected Relevant Publications 
171. Leclerc, G., Isner, J.M., Kearney, M„ Simons, M., Safian, R.D., Baim, D.S., Weir, L.: Evidence 
implicating nonmuscle myosin in restenosis: use of in situ hybridization to analyze human vascular lesions 
obtained by directional atherectomy. Circulation 85:543-553, 1992. 
173. Pickering, J.G., Weir, L., Rosenfield, K., Stetz, J., Isner, J.M.: Smooth muscle cell outgrowth from 
human atherosclerotic plaque: implications for the assessment of lesion biology. Journal of the American 
College of Cardiology 20:1430-1439, 1992 
177. Leclerc G., Gal, D., Nikol, S., Kearney, M., Weir, L., Isner, J.M.: Percutaneous arterial gene transfer 
in a rabbit model efficiency in normal and balloon-dilated atherosclerotic arteries Journal of Clinical 
Investigation 90:936-944, 1992. 
184. Nikol, S., Isner, J.M., Pickering, J.G., Kearney, M., Leclerc, G., Weir, L.: Expression of 
transforming growth factor-61 is increased in human vascular restenosis lesions. Journal of Clinical 
Investigation 90:1582-1592, 1992. 
186. Isner J.M., Rosenfield, K.: Reducing the cardiac complications of peripheral vascular surgery. 
Proceedings of the Mayo Clinic 67:95-98, 1992. 
190. Simons, M., Leclerc, G., Safian, R.D., Isner, J.M.,Weir, L., Baim, D.S.: Relation between activated 
smooth muscle cells in coronary artery lesions and restenosis after atherectomy. New England Journal 
of Medicine 328:608-613, 1993. 
191. Pickering, J.G., Bacha, P.A., Weir, L., Jekanowski, J., Nichols, J.C., Isner, J.M.: Prevention of 
smooth muscle cell outgrowth from human atherosclerotic plaque by a recombinant cytotoxin specific for the 
epidermal growth factor receptor. Journal of Clinical Investigation 91:724-729, 1993. 
192. Losordo, D.W., Leclerc, G., Gal, D., Weir, L., Takeshita, S., Isner, J.M.: Use of the rabbit ear artery 
t serially assess foreign protein secretion after site-specific arterial gene transfer in vivo: Evidence that 
natomic identification of successful gene transfer may underestimate the potential magnitude of transgene 
expression. Circulation 89:785-792, 1994. 
Recombinant DNA Research, Volume 20 
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