FF 
Principal investigator Program Director (Last, first, middle!: 
J e ffr ey Michael 
BIOGRAPHICAL SKETCH 
Give the following information for the key Dersonnei and consultants and collaOorators. Begin with the principal 
investigator/program oirector Photocooy this page for each oerson. 
AME ■ POSITION TITLE 
Kenneth Walsh Investigator/Research Director 
EDUCATION ( Begin witn baccalaureate or otner initial ororessionai education, sucn as nursing, and include postdoctoral training.! 
INSTITUTION AND LOCATION 
DEGREE 
vp a n 
CONFERRED 
FIELD OF STUDY 
Bowling Green State University 
B.S. 
1978 
Chemistry 
University of California, Berkeley 
Ph.D. 
} 
i 
• 
1984 
Biochemistry 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, expenence. and 
honors. Key personnel include the pnncipal investigator and any other individuals who participate in the scientific development or execution of the protect. 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some protects will include individuals at the masters or 
baccalaureate level provided they contnbute in a substantive way to the scientific development or execution of the project. Include present membership on 
any Federal Government public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the 
past three years and to representative earlier publications oertment to this application. If the list of publications in the last three years exceeds two pages, 
select the most pertinent publications. DO NOT EXCEED TWO PAGES. 
Academic and Research Appointments: 
1977- 1978: Undergraduate Research, Department of Chemistry, Bowling Green State University. Advisor: A. Daffom. 
1978- 1979: Postgraduate Research, Department of Biochemistry , Medical College of Ohio. Advisor: E.M. Reimann. 
1979- 1985: Graduate Student, Department of Biochemistry, University of California, Berkeley. Advisor: D.E. Koshland. 
1985-1988: Postdoctoral Fellow, Department of Biology, Massachusetts Institute of Technology. Advisor: P. Schimmel. 
1989-1993: Assistant Professor, Department of Physiology and Biophysics, Case Western Reserve University 
1991-present: Adjunct Assistant Professor, Department of Biochemistry, Case Western Reserve University. 
1993-present: Investigator and Research Director, Department of Cardiovascular Research, St. Elizabeth's Medical Center; 
Associate Professor, Department of Medicine; Adjunct Associate Professor, Department of Anatomy and Cell 
Biology and Graduate Program in Cell, Molecular and Developmental Biology (pending), Tufts University. 
Awards and Honors: AHA Irvine H. Page Arteriosclerosis Research Award, 1993; Established Investigator of the 
American Heart Association, 1990-1995; AHA Young Investigator Award, Molecular and Cellular Biology of the Vascular 
Wall, 1993; Mathers Foundation Young Investigator, 1989-1993; Life and Health Insurance Medical Research Fund Award, 
1989 - 1992; National Research Service Award Fellowship, 1987-1989; Postdoctoral Fellow of the Muscular Dystrophy 
Association, 1986-1987; B.S. Magna cum laude B.G.S.U. 1978. 
Advisory Committees: Molecular Biology of Muscle Study Section, National American Heart Association, 1991-95; 
Cardiovascular A Study Section, NHLBI (Ad hoc) 1992; Committee on Scientific Sessions Program, National AHA, 1990-92; 
Student Selection Committee, AHA Northeast Ohio Affiliate, 1993. 
Publications; 
K. Walsh, D. M. Millikin, K. K. Schlender and E. M. Reimann (1979). Calcium-dependent phosphorylation of glycogen 
synthase by phosphorylase kinase, J. Biol. Chem. 254, 6611-6616. 
K. Walsh, D. M. Millikin, K. K. Schlender and E. M. Reimann (1980). Stimulation of phosphorylase b kinase by the 
calcium-dependent regulator. J. Biol. Chem. 255, 5036-5042. 
A. Daffom, J.P. Neenan, Ash, C.P., Betts, L., Finke, J.M., Garman, J.A., Rao, M., Walsh, K. and Williams, R.R. (1982). 
Acetylcholinesterase inhibition by the ketone transition state analog phenoxyacetone and l-halo-3-phenoxy 
2-propanones, Biochem. Biophys. Res. Comm. 104, 597-602. 
K. Walsh and D. E. Koshland, Jr. (1984). Determination of flux through the branch point of two metabolic cycles. The 
tricarboxylic acid cycle and the glyoxylate shunt. J. Biol. Chem. 259, 9646-9654. 
D. C. LaPorte, K. Walsh and D. E. Koshland, Jr. (1984). The branch point effect: Ultrasensitivity and subsensitivity to 
metabolic control. J. Biol. Chem. 259, 14068-14075. 
D. E. Koshland, Jr., K. Walsh and D. C. LaPorte (1985). Sensitivity of metabolic fluxes to covalent control. Curr. Top. Cell. 
Reg. 27, 13-22. 
K. Walsh and D. E. Koshland, Jr. (1985). Branch point control by the phosphorylation state of isocitrate dehydrogenase. A 
quantitative examination of fluxes during a regulatory transition. J. Biol. Chem. 260, 8430-8437. 
K. Walsh and D. E. Koshland, Jr. (1985). Characterization of rate-controlling steps in vivo using an adjustable expression 
v*»«-tnr Pmr Nml. Acad. Sci. USA 82. 3577-3581. 
Recombinant DNA Research, Volume 20 
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