Princioal Investigator/Program Director f Last . first, middle): WALSH, KENNETH 
K. Walsh, M. Schena, A. J. Flint and D. E. Koshland (1986). Compensatory regulation in metabolic pathways - responses to 
increases and decreases in citrate synthase levels. Biochem. Soc. Symp. 54, 183-195. 
K. Walsh and P. Schimmel (1987) Two nuclear factors compete for the skeletal muscle actin promoter. J. Biol. Chem.262, 
9429-9432. 
K. Walsh and P. Schimmel (1988). DNA binding site for two skeletal actin promoter factors is important for expression in 
muscle cells. Mol. Cell. BiolS, 1800-1802. 
K. Walsh and P. Schimmel (1988). Preliminary characterization of muscle actin promoter factors 1 and 2 and their interaction 
with the skeletal actin promoter. Mol. Cell. Biol. New Ser., 93, 669-676. 
K. Walsh (1989). Cross-binding of nuclear factors to functionally different promoter elements in the c-fos and skeletal actin 
genes. Mol. Cell. Biol. 9, 2191-2201. 
I.M. Santoro, T.-M. Yi and K. Walsh (1991). Identification of single-stranded DNA-binding activities that interact with 
muscle gene elements. Mol. Cell. Biol., 11, 1944-1953. 
H. Ernst, K. Walsh, C.A. Harrison and N. Rosenthal (1991). A fragment of the MLC1/3 enhancer contains a binding site for 
the skeletal actin promoter factors MAPF1 ad MAPF2 and can function as an orientation-dependent promoter element. 
Mol. Cell. Biol. 11, 3735-3744. 
T.-M. Yi, K. Walsh and P. Schimmel (1991). Rabbit muscle creatine kinase: Genomic cloning, sequencing, and analysis of 
upstream sequences important for expression in myocytes. Nucl. Acids Res. 19, 3027-3033. 
I. M. Santoro and K. Walsh (1991). Natural and synthetic CArG elements differ in expression and protein-binding properties. 
Mol. Cell. Biol. 11, 6296-6305. 
A. Gualberto, R.M. Patrick and K. Walsh (1992). Nucleic acid specificity of a vertebrate telomere-binding protein: Evidence for 
G G base pair recognition at the core binding site. Genes & Devel. 6, 815-824. 
K. Walsh and A. Gualberto (1992). MyoD binds to the guanine tetrad nucleic acid structure. J. Biol. Chem. 267, 13714-18. 
A. Gualberto, D. LePage, G. Pons, R.M. Patrick, S.L. Mader, K. Park, M.L. Atchison and K. Walsh (1992). Functional 
antagonism between YY1 and the serum response factor. Mol. Cell. Biol. 12, 4209-4214. 
C.V. Patel, D.H. Gorski, D.F. LePage and K. Walsh (1992). Molecular cloning of a homeobox transcription factor from adult 
aortic smooth muscle. J. Biol. Chem. 267, 26085-26090. 
C. K. Vincent, A. Gualberto, C.V. Patel and K. Walsh (1993). Different regulatory sequences control creatine kinase-M gene 
expression in directly injected skeletal and cardiac muscle. Mol. Cell. Biol. 13, 1264-1272. 
D. H. Gorski, D.F. LePage, C.V. Patel, N. G. Copeland, N. A. Jenkins and K. Walsh (1993). Molecular cloning of a 
divergent homeobox gene that is rapidly down-regulated during the G()/Gi transition in vascular smooth muscle cells. 
Mol. Cell. Biol. 13, 3722-3733. 
K. Walsh (1993). MyoD and c-fos expression. Nature 365, 61 1-612. 
D. H. Gorski, D. F. LePage and K. Walsh (1994). Cloning and sequence analysis of homeobox transcription factor cDNAs 
with and inosine-containing probe. Biotechniques. 16, 856-865. 
K. A. Martin, K. Walsh and S.L. Mader (1994). Paired E-box elements confer muscle-specific expression to a heterologous 
promoter. Gene. In press. 
P. Ruiz-Lozanol, L. de Lecea, C. Buesa, P. Perez de la Ossal, D. LePage, A. Gualberto, K. Walsh and G. Pons. The gene 
encoding rat phosphoglycerate mutase subunit M: cloning and promoter analysis in skeletal muscle cells. Submitted. 
A. Gualberto, J. Lowry, I.M. Santoro and K. Walsh. Parameters that influence the extent of site occupancy by a candidate 
telomere end-binding protein. Submitted. 
M.S. Simonson, K. Walsh, C.C. Kumar, P. Bushel and W. Herman. Two proximal CArG elements mediate serum-inducible 
activity of the smooth muscle a actin promoter, a genetic marker of the activated phenotype of mesangial cells. 
Submitted. 
D.H. Gorski, D.J. Suciu and K. Walsh. Inhibition of vascular smooth muscle proliferation by a diverged homeoprotein. 
Submitted. 
D.F. LePage, D.A. Altomare, J.R. Testa and K. Walsh. Molecular cloning and localization of the human GAX gene to 7p21. 
Submitted. 
Lectures at Symposia (1993- ): 
Experimental Biology (1993), Blood Vessel Club, New Orleans, LA 
American Heart Association, Molecular and Cellular Biology of the Vascular Wall (1993), Boston, MA. 
AHA 66th Scientific Sessions (1993), Recent Advances in Cardiac Development, Atlanta, GA. 
AHA 66th Scientific Sessions (1993), Council on Arteriosclerosis Irwin H. Page Lecture, Atlanta, GA. 
Keystone Symposium (1994), Molecular Biology of Muscle Development, Snowbird, Utah. 
Experimental Biology (1994), Gene Expression and Vascular Injury, Anaheim, CA. 
Transgenics and Gene Transfer Technology in Cardiovascular Research (1994), Wuppertal, Germany 
Vascular Biology Gordon Conference, New London, NH. 
[3461 
Recombinant DNA Research, Volume 20 
