Gene Therapy of Malignant Mesothelioma 
Using El Deleted Adenoviruses Containing the Herpes Simplex Thymidine Kinase 
Gene: A Phase I Trial 
University of Pennsylvania Medical Center 
Principal Investigator: Steven M. Albelda, M.D. 
Associate Professor, Department of Medicine 
Co Investigators: Joseph Treat, M.D. 
Associate Professor, Department of Medicine 
Larry R. Kaiser, M.D. 
Associate Professor, Department of Surgery 
Mariann Grossman, B.S. 
Director, Human Applications Laboratory 
Leslie Litzky, M.D. 
Assistant Professor, Department of Pathology 
Arthur Caplan, Ph.D. 
Professor, Department of Molecular and Cellular Engineering 
Director, Center for Biomedical Ethics 
James M. Wilson, M.D., Ph.D. 
Professor and Chairman 
Department of Molecular and Cellular Engineering 
Director, Institute for Human Gene Therapy 
Recombinant DNA Research, Volume 20 
[393] 
