Attad-msnt II - F^ge 1 
HUMAN GENE TRANSFER PROTOCOLS 
8810-001® 
(M/TIL) 
Rosenberg, Steven A.; National Institutes of Health, Bethesda, Maryland; The Treatment of Patients 
with Advanced Cancer Using Cyclophosphamide, Interleukin-2 and Tumor Infiltrating Lymphocytes. 
RAC Approval: 10-3-88/NIH Approval: 3-2-89 
Minor Modification: 3-30-90 
9007-002 a,b 
(T/IGD/SCID-ADA) 
Blaese, R. Michael; National Institutes of Health, Bethesda, Maryland; Treatment of Severe 
Combined Immune Deficiency (SCID) due to Adenosine Deaminase (ADA) Deficiency with 
Autologous Lymphocytes Transduced with the Human ADA Gene: An Experimental Study 
RAC Approval: 7-31-90/NIH Approval: 9-6-90 
Major Amendment /RAC Approval: 2-10-92 
Major Amendment/NIH Approval: 4-22-92 
Minor Modification: 4-21-93 
Minor Modification: 6-7-93 
9007-003® 
(T/C) 
Rosenberg, Steven A.; National Institutes of Health, Bethesda, Maryland; Gene Therapy of Patients 
with Advanced Cancer Using Tumor Infiltrating Lymphocytes Transduced with the Gene Coding for 
Tumor Necrosis Factor. 
RAC Approval: 7-31-90/NIH Approval: 9-6-90 
Minor Modification: 2-17-94 
9102-004® 
(M/BM) 
Brenner, Malcolm K.; Mirro, Joseph; Hurwitz, Craig; Santana, Victor; and Ihle, James; St. Jude 
Children’s Research Hospital, Memphis, Tennessee; Autologous Bone Marrow Transplant for 
Children with Acute Myelogenous Leukemia in First Complete Remission : Use of Marker Genes to 
Investigate the Biology of Marrow Reconstitution and the Mechanism of Relapse. 
RAC Approval: 2-4-91/NIH Approval: 7-12-91 
Minor Modification: 11-91 
CLOSED: 1-15-93 
9105-005® 
(M/BM) 
Brenner, Malcolm K.; Mirro, Joseph; Santana, Victor; and Ihle, James; St. Jude Children’s Research 
Hospital, Memphis, Tennessee; A Phase I/II Trial of High Dose Carboplatin and Etoposide with 
Autologous Marrow Support for Treatment of Stage D Neuroblastoma in First Remission: Use of 
Marker Genes to Investigate the Biology of Marrow Reconstitution and the Mechanism of Relapse. 
RAC Approval: 5-31-91/NIH Approval: 7-12-91 
Minor Modification: 11-91 
CLOSED: 6-1-92 
9105-006® 
(M/BM) 
Brenner, Malcolm K.; Mirro, Joseph; Santana, Victor; and Ihle, James; St. Jude Children’s Research 
Hospital, Memphis, Tennessee; A Phase II Trial of High-Dose Carboplatin and Etoposide with 
Autologous Marrow Support for Treatment of Relapse/Refractory Neuroblastoma Without Apparent 
Bone Marrow Involvement. 
RAC Approval: 5-31-91/NIH Approval: 7-12-91 
Minor Modification: 11-91 
CLOSED: 4-9-93 
Recombinant DNA Research, Volume 20 
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