Attarhrent II - F^ge 8 
9306-EXP 
9306-050 
9306-051 
9306-052 
9309-053* 
9309-054 
9309-055 
9309-056 
(T/V/C/Glloblastoma) 
Sobol, Robert and Royston, Ivor; San Diego Regional Cancer Center, San Diego, California; Phase I 
Study of Cytokine Gene Therapy of Cancer Active Immunotherapy of Glioblastoma with Tumor Cells 
or Fibroblasts Genetically Modified to Secrete Interleukin-2. 
NIH Approval: 12-28-92 
Major Amendment (Expedited Review)/NIH Approval: 5-11-93 
CLOSED: 10-20-93 (Patient death) 
(T/C/Astrocytoma) 
RafTel, Corey, Childrens Hospital Los Angeles, Los Angeles, California, and Culver, Kenneth; Iowa 
Methodist Medical Center, Des Moines, Iowa; Gene Therapy for the Treatment of Recurrent Pediatric 
Malignant Astrocytomas with In Vivo Tumor Transduction with the Herpes Simplex Thymidine Kinase 
Gene. 
RAC Approval: 6-8-93/NIH Approval: 9-3-93 
(T/C/Breast/Ovarian/Brain) 
Hesdorffer, Charles and Antman, Karen; Columbia University College of Physicians and Surgeons, 
New York, New York; Human MDR Gene Transfer in Patients with Advanced Cancer. 
RAC Approval: 6-8-93/NIH Approval: 9-3-93 
(T/V/C/Glioblastoma) 
Ilan, Joseph; Case Western Reservq University School of Medicine and University Hospitals of 
Cleveland, Cleveland, Ohio; Gene Therapy for Human Brain Tumors Using Episome-Based Antisense 
cDNA Transcription of Insulin-Like Growth Factor I. 
RAC Approval: 6-8-93/NIH Approval: 12-2-93 
(T/V/C/Small Cell Lung Cancer) 
Cassileth, Peter; Podack, Eckhard R.; Sridhar, Kasi; University of Miami, and Savaraj, Niramol; 
Miami Veterans Administration Hospital, Miami, Florida; Phase I Study of Transfected Cancer Cells 
Expressing the Interleukin-2 Gene Product in Limited Stage Small Cell Lung Cancer. 
RAC Approval: 9-9-93/NIH Approval: 12-2-93 
Minor Modification: 3-23-94 
(T/C/Breast) 
O’Shaughnessy, Joyce; National Institutes of Health, Bethesda, Maryland; Retroviral Mediated 
Transfer of the Human Multi-Drug Resistance Gene (MDR-1) into Hematopoietic Stem Cells During 
Autologous Transplantation after Intensive Chemotherapy for Breast Cancer. 
RAC Approval: 9-9-93/NIH Approval: 10-7-93 
(T/C/Brain) 
Kun, Larry E.; Sanford, R. A.; Brenner, Malcolm K.; and Heideman, Richard L.; St. Jude Childrens 
Research Hospital, Memphis, Tennessee; and Oldfield, Edward H.; National Institutes of Health, 
Bethesda, Maryland; Gene Therapy for Recurrent Pediatric Brain Tumors. 
RAC Approval: 9-9-93/NIH Approval: 10-7-93 
(T/V/C/Melanoma) 
Das Gupta, Tapas K. and Cohen, Edward P.; University of Illinois at Chicago; Chicago, Illinois; 
Immunization of Malignant Melanoma Patients with Interleukin 2-Secreting Melanoma Cells Expressing 
Defined Allogeneic Histocompatibility Antigens. 
RAC Approval: 9-10-93/NIH Approval: 4-19-94 
[496] 
Recombinant DNA Research, Volume 20 
