Adenovirus-Mediated Gene Transfer for Cystic Fibrosis: Safety of Single Administration in the Lung 
CVs 
FF 
Principal Investigator/Program Director (Last, first, middle): 
BIOGRAPHICAL SKETCH 
H. Dorkin, A. Lapey, A. E. Smith 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME 
POSITION TITLE 
Dorkin, Henry L., M.D. 
Chief, Pediatric Pulmonology and Allergy 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and indude postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Lehigh University 
BS 
1970 
Engineering 
Johns Hopkins University 
MD 
1974 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, 
experience, and honors. Key personnel include the principal investigator and any other individuals who participate in the scientific 
development or execution of tne project Key personnel typically will include all individuals with doctoral or other professional degrees, but in 
some projects will include Individuals at the masters or baccalaureate level provided they contribute in a substantive way to the scientific 
development or execution of the project. Include present membership on any Federal government public advisory committee. List, in 
chronological order, the titles, all authors, and complete references to all publications during the past three years and to representative earlier 
publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
Year 
Position 
institution 
1974- 75 
1975- 76 
1976- 77 
1977- 80 
1979- 81 
1980- 82 
1981- 88 
1981 -present 
1988-present 
Intern 
Assistant Resident 
Senior Assistant Resident 
Research Fellow 
Instructor 
Assistant in Medicine 
Assistant Professor 
Chief, Div. Pediatric Pulm. & Allergy 
Associate Professor 
Johns Hopkins Hospital, Baltimore, MD 
Johns Hopkins Hospital, Baltimore, MD 
Johns Hopkins Hospital, Baltimore, MD 
Children’s Hospital Medical Center, Boston, MA 
Harvard Medical School, Boston, MA 
Children’s Hospital Medical Center, Boston, MA 
Tufts University School of Medicine, Boston, MA 
New England Medical Center, Boston, MA 
Tufts University School of Medicine, Boston, MA 
Year 
Honor 
1970 
1970 
1977-80 
1986,1990 
1988 
BS cum laude with Departmental honors, Lehigh University 
Tau Beta Pi - National Engineering Honorary 
Parker B. Francis Foundation Pulmonary Research Fellowship 
Louis Bartoshesky Award, Department of Pediatrics, Tufts University School of Medicine, for 
excellence in patient care 
Endowed Lectureship, “Advances in Cystic Fibrosis", Elissa R. Klein Lecture, University of 
Massachusetts Medical Center, Worcester, MA 
Bibliography — Papers Published or In Press 
Dorkin, HL, Jackson AC, Strieder DJ and Dawson SV. Interaction of oscillator and unidirectional flows in straight 
tubes and an airway cast. J Appl Physiol: Resp, Environm, and Exer Physiol 1982; 52:1097-1 105. 
Schwartz AM, Dorkin HL and Carter BL. CT appearance of the liver in a patient with biliary cirrhosis and cystic 
fibrosis. J Computer Assisted Tomography. 1983; 7:530-533. 
Dorkin HL, Stark AR, Werthammer JW, Strieder DJ, Fredberg JJ and Franz III ID. Respiratory system impedance 
from 4 to 40 Hz in paralyzed intubated infants with respiratory disease. J Clin Invest 1 983; 72:903-91 0. 
Dorkin HL, Lutchen KR and Jackson AC. Respiratory system impedance measurements from 4-200 Hz in normal 
humans. Fed Proc 1986; 45:873. J Appl Physiol 1988; 64:(2):823-831. 
Jefferson DC, Marini FC, Dorkin HL and Arias IM. Long Term Culture of CF Nasal Airway Epithelial Cells. Pediatr 
Pulmonol 1988; A48, Supplement 2. 
Dorkin HL, Lutchen KR, Giurdanella CA, Renzi PE, Jackson AC. Gas Density Dependence of Respiratory System 
Impedances (Zrs) in Humans Between 2 and 320 Hz. Fed Proc March, 1989; (presentation - FASEB, 
1989). 
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Recombinant DNA Research, Volume 20 
