Adenovirus-Mediated Gene Transfer for Cystic Fibrosis: Safety of Single Administration in the Lung 
FF Principal Investigator/Program Director (Last, first, middle): f~| Qgrkin A. Lapey, A E Smith 
Klein JD, Dorkin HL, Weiss ST. Epidemiology of Environmental Tobacco Smoke Exposure and Other Respiratory 
Risk Factors in a Population of Children with Cystic Fibrosis. Am Rev Respir Dis 1989; 139 (4 part 2):A565. 
Dorkin, HL, Lutchen KR, Habib RH and Jackson AC. Response of Respiratory Input Impedance Acoustic 
Resonance to Bronchodilator. Am Rev Respir Dis 1990; 141 (4) part II, A851 (presentation - May 1990). 
Lutchen KR, Habib RH, Dorkin HL and Wall MA. Respiratory impedance and multibreath N2 washout in healthy, 
asthmatic and cystic fibrosis subjects. J Appl Physiol 1990; 68(5):2139-2149. 
Jefferson DM, Valentich JD, Marini FC, Grubman SA, lannuzzi MC, Dorkin HL, Li M, Klinger KW, Welsh MJ. 
Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines'. Amer J Physiol 
1990;259:L496-505. 
Neff KM, Dorkin HL, Lutchen KR and Jackson AC. Oscillatory impedance of the respiratory system in infants 
measured between 4 and 256 Hz. Am Rev Respir Dis, April, 1992; 145:A253. 
Dorkin HL, Neff KM, Lutchen KR, Jackson AC. Serial measurement of respiratory system impedance and 
ventilation inhomogeneity in patients with cystic fibrosis (Abstract WP86 in “Proceedings of the 1 1th 
International CF Conference”, Dublin, Ireland 1992). 
Tucker LB, Miller LC, Marx G, Dorkin HL, Schaller JG. Cardiopulmonary manifestations in childhood systemic 
lupus erythematosus (SLE)-abstract D81. Arthritis and Rheumatism 35(9):S227 (Supplement) September 1992. 
Dorkin HL. Home care of the patient with bronchopulmonary dysplasia, in Frantz ID (ed): Tufts University School of 
Medicine and Floating Hospital for Children Reports on Neonatal Respiratory Diseases, vol 2(4), 1992. 
Ramsey BW, Dorkin HL, Eisenberg J, Gibson RL, Harwood I, Kravitz R, Lemen R, Schidlow D, Astley SJ, McBumie 
MA, Hedges D, McNamara S, Weber A, Williams-Warren J, Cohen M, Smith AL. Efficiency of aerosol 
administration of tobramycin in patients with cystic fibrosis. N Engl J Med 1993; 328:1740-46. 
Richards B, Skoletsky J, Shuber AP, Balfour R, Stem RC, Dorkin HL, Parad RB, Witt D, Klinger KW. Multiplex PCR 
amplification from the CFTR gene using DNA prepared from buccal brushes/swabs. Human Molecular Genetics 
1993 (2):2, 159-1 63. 
Ramsey BW, Colin A, Dorkin HL, Eisenberg J, Gibson RL, Harwood I, Kravitz R, Lemen R, Schidlow D, Astley SJ, 
McBumie MA, Hedges D, McNamara S, Weber A, Williams-Warren J, Cohen M, Smith A.. A phase II trial of 
inhaled rhDNase in patients with cystic fibrosis. Am Rev Repir Dis 1993 (148:2). 
Dorkin HL. Bronchiolitis, in Dershowitz RA (ed): Ambulatory Pediatric Care (2nd edition). Philadelphia, J.B. 
Lippincott, 1993. 
Mulberg AE, Grubman SA Perrone RD, Rogers LC, Lee DW, Murray SL, Wolkoff LI, Dorkin HL, Jefferson DM. 
Human intrahepatic biliary epithelial cell lines for the study of cystic fibrosis-related hepatobiliary disease. 
Pediatr Pulmonol 9:221 -A70 (Supplement) September, 1993. 
Neff KM, Dorkin HL, Lutchen KR, Jackson AC. Respiratory input impedance (Zrs) and moment analysis of 
multibreath nitrogen washout (MBNW) in infants with respiratory disease. Am Rev Respir Dis, April, 1994; 
149(4):A37. 
Konstan MW, Stone PJ, Berger M, Dorkin HL, Franzblau C, Snider GL. Elastin and collagen degradation products 
in urine of patients with cystic fibrosis. Am Rev Respir Dis, April 1994; 149 (4):A668. 
O’Sullivan B, Dorkin, HL.. Nutritional Considerations in Cystic Fibrosis 1 , in Baker and Baker (ed): Pediatric Enteral 
Nutrition. New York, Chapman and Hall, 1 994. 
Dorkin, HL, Schidlow DV, Wilmott RW (Editors): Cystic Fibrosis - Pathogenesis and New Therapies. Genentech 
Modular Slide Library and Lecture Support Program, 1994. 
Jackson AC, Neff KM, Lutchen KR, Dorkin HL. Interpretation of respiratory system impedance (4-256Hz) in healthy 
infants. Eur Respir Rev 1994 (in press). 
Dorkin HL. Bronchopulmonary Dysplasia; in Schidlow and Smith (ed): Pediatric Respiratory Disease (in press). 
Grubman SA, Fang SL, Mulberg AE, Rogers LC, Lee DW, Murray SL, Perrone RD, Dorkin HL, Cheng SH, Smith 
AE, Jefferson DM. CFTR gene complementation in intrahepatic biliary epithelial cell lines derived from CF 
patients (submitted 1994). 
Neff KM, Dorkin HL, Lutchen KR, Jackson AC. Interpretation of respiratory impedance measurements of healthy 
infants (submitted). 
Recombinant DNA Research, Volume 20 
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