Adenovirus-Mediated Gene Transfer for Cystic Fibrosis: Safety of Single Administration in the Lung 
FF 
Principal Investigator/Program Director (Last, first, middle): |-| Dorkin, A. Lapey, A. E Smith 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME 
Lapey, Allen M.D. 
POSITION TITLE 
Associate Pediatrician, Massachusetts General Hospital 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD’OF STUDY 
Williams College, Williamstown, MA 
BA 
1961 
University of Rochester, Rochester, NY 
MD 
1966 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, 
experience, and honors. Key personnel include the principal investigator and any other individuals who participate in the scientific 
development or execution of the project. Key personnel typically will include all individuals with doctoral or other professional degrees, but in 
some projects will include individuals at the masters or baccalaureate level provided they contribute in a substantive way to the scientific 
development or execution of the project. Include present membership on any Federal government public advisory committee. List, in 
chronological order, the titles, all authors, and complete references to all publications during the past three years and to representative earlier 
publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
Year Position Institution 
1966- 67 
1967- 68 
1968- 70 
1970-72 
1970-72 
1972-present 
1972-73 
1972- 73 
1973- present 
1973- 89 
1974- 88 
1982-present 
1989- present 
1 990- present 
Intern 
Assistant Resident, Pediatrics 
Clinical Associate, Pediatric Metabolism 
Clinical and Research Fellow 
Clinical Trainee 
Dir., Ped. Resp. Ambulatory Care 
Instructor in Pediatrics 
Assistant in Pediatrics 
Dir., Cystic Fibrosis Center 
Clinical Instructor in Pediatrics 
Assistant Pediatrician 
Founder and Director 
Associate Pediatrician 
Clin. Assist. Prof, of Pediatrics 
University of Rochester, Rochester, NY 
Children's Hospital Medical Center 
National Institutes of Health, Bethesda, MD 
Massachusetts General Hospital, Boston, MA 
National Cystic Fibrosis Research Foundation 
Massachusetts General Hospital, Boston, MA 
Harvard Medical School, Cambridge, MA 
Massachusetts General Hospital, Boston, MA 
Massachusetts General Hospital, Boston, MA 
Harvard Medical School, Cambridge, MA 
Massachusetts General Hospital, Boston, MA 
New England Pediatric Pulmonary Consortium 
Massachusetts General Hospital, Boston, MA 
Harvard Medical School, Cambridge, MA 
Year Honor 
1 966 Alpha Omega Alpha 
1992 The Best Doctors in America 
£ 
' 
| 
I 
I 
Bibliography — Papers Published or In Press 
Lapey A. Cystic Fibrosis in Ambulatory Pediatric Care 2nd Ed. 1993:626-630. 
Lapey A. Asthma in Ambulatory Pediatric Care 2nd Ed. 1993:182-188. 
Rubin DS, Perrin J, Arnett H, Jellinek M, Lapey A and Murphy JM. Parental perception of uncertainty: Impact on 
children with chronic asthma. Submitted to J Pediatrics, Aug. 1994. 
Kinane BT, Mansell AL, Lapey A, Zwerdling RG, Shannon DC. Follicular bronchitis in the pediatric population. 
Chest 1993; 104:1183-86. 
Anbar RD, Lapey A, Khaw KT, Spragg J, Strieder DJ, Shaw LF, Kelly DH, Shannon DC. Does lithium carbonate 
affect the ion transport abnormality in cystic fibrosis? Pediatric Pulmonology 1990;8:82-88. 
Lapey A. Cystic Fibrosis in Pulmonary Medicine: Problems in Primary Care, Ed. Brandstetter RD. Medical 
Economics Books, Oradell, NJ. 1989:602-608. 
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Recombinant DNA Research, Volume 20 
