PROTOCOL 
PHASE I TRIAL OF INTERLEUKIN-2 PLASMID DNA/DMRIE/DOPE LIPID 
COMPLEX AS AN IMMUNOTHERAPEUTIC AGENT Protocol 
IN SOLID MALIGNANT TUMORS OR LYMPHOMAS 
BY DIRECT GENE TRANSFER 
PRINCIPAL INVESTIGATOR: 
Evan M. Hersh, MD 
Hematology/Oncology 
Arizona Cancer Center 
Tucson, A Z 85724 
CO-PRINCIPAL INVESTIGATORS: 
Emmanuel Akporiaye, PhD 
David Harris, PhD 
Alison T. Stopeck, MD 
Evan C. Unger, MD 
James A. Wameke, MD 
Sponsor: 
Vical Inc. 
Alain B. Schreiber, MD 
9373 Towne Centre Drive 
Suite 100 
San Diego, CA 92121 
Date: 
July 7, 1994 
Recombinant DNA Research, Volume 20 
[599] 
