SUBJECTS’ CONSENT FORM Page _5_of_6 
Appr. Date;8/4/94 TITLE: Phase I Trial, of Interleukin-2 Plasmid Number 
DNA DMRIE/DOPE Lipid Complex as an 1mm u no- SWOG: 
therapeutic Agent in Solid Malignant Tumors HSC:94-129 
or Lymphomas by Direct Gene Transfer(VCL 1 102) 
I-D-2-a-6 PARTICIPATION COSTS 
The experimental drug, namely the LL-2 gene in a plasmid liposome (fatty 
substance) delivery system will be supplied by the study sponsor. Its full name 
is IL-2 DNA DMRIE/DOPE Either I or my insurance company will be charged 
for the standard tests associated with the delivery of routine medical care for 
my disease. This includes routine blood tests. X-rays, scans, and physician’s 
charges. The charges associated with the management of the side effects of 
treatment (medication, etc.) will also be billed to me or a third party carrier. 
All costs are standard for medical care involving these treatments. The drug 
and its ad min istration and any additional testing will be covered by the 
sponsor. I can obtain further information from Evan M. Hersh, M.D. (Principal 
Investigator) at (602) 626-2250 or page at 694-6000, (pager 1240), Evan Unger, 
MD. (602) 694-2515 (pager 2042), James Wameke, M.D. (602) 626-7754 (pager 
2429) or Alison Stopeck, M.D. (602) 626-2816 (pager 1231). 
LIABILITY 
I understand that adverse reactions are possible in any research program 
despite the use of high standards of care and could occur through no fault of 
mine or the investigator involved. Reactions which can be foreseen have 
been described in this consent form. However, unforeseeable harm may also 
occur and may require care. 
I understand that money for research-related side effects or harm or for 
wages or time lost is not available. Necessary emergency medical care directly 
related to this treatment will be provided from Evan M. Hersh, M.D. through 
the University of Arizona Health Sciences Center. I can obtain further 
information from Evan M Hersh, MD. (Principal Investigator) at (602) 626- 
2250), Evan Unger, MD. (602) 694-2515 (pager 2042), James Wameke, M.D. (602) 
626-7754 (pager 2429) or Alison Stopeck, MD. (602) 626-2816 (pager 1231). If I 
have questions concerning my rights as a research subject, I may call the 
Human Subjects Committee office at (602) 626-6721. 
AUTHORIZATION 
BEFORE GIVING MY CONSENT BY SIGNING THIS FORM, THE METHODS, 
INCONVENIENCES, RISKS AND BENEFITS HAVE BEEN EXPLAINED TO ME AND MY 
QUESTIONS HAVE BEEN ANSWERED. I UNDERSTAND THAT I MAY ASK QUESTIONS 
-_ D _2-a-3 AT ANY TIME AND THAT I AM FREE TO WITHDRAW FROM THE PROJECT AT ANY 
TIME WITHOUT CAUSING BAD FEELINGS OR AFFECTING MY MEDICAL CARE. MY 
PARTICIPATION IN THIS PROJECT MAY BE ENDED BY THE INVESTIGATOR OR BY 
THE SPONSOR FOR REASONS THAT WOULD BE EXPLAINED. NEW INFORMATION 
DEVELOPED DURING THE COURSE OF THIS STUDY WHICH MAY AFFECT MY 
WILLINGNESS TO CONTINUE IN THIS RESEARCH PROJECT WELL BE GIVEN TO ME AS 
IT BECOMES AVAILABLE I UNDERSTAND THAT THIS CONSENT FORM WILL BE 
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Recombinant DNA Research, Volume 20 
