7 . Because the effects of treatment with the modified virus and with the p53 gene are 
not known, it is possible that the treatment might somehow cause the tumor(s) in 
my liver to progress or worsen. 
Risks Associated with CT and MRI Scans 
CT scans and MRI scans are painless procedures that are commonly used in cancer 
treatment and are generally extremely safe. 
Risks Associated with Hepatic Angiogram 
A hepatic angiogram is a commonly used procedure to evaluate the arteries in and around 
the liver. It involves inserting a catheter (thin tube) into an artery in my groin and then 
guiding the catheter to the hepadc (liver) artery using X-ray pictures. Dye is put into the 
catheter to allow the doctors to take additional X-ray pictures of the arteries. Potential 
complications from this procedure include a reaction to the dye, infection, and bleeding. If 
my doctors and I have decided that I undergo an operation to receive a hepatic artery 
infusion pump (a device requiring an operation for placement which can administer 
chemotherapy into the liver), the hepatic angiogram, which is necessary to evaluate me for 
the operation, can also be used for this study. 
Risks Associated with Surgery 
The surgical risks associated with the operation are likely to be the same whether or not I 
participate in the study. The operation will be conducted in the same fashion, except for the 
additional procedure that biopsies will be obtained of my liver tumor and of normal sections 
of my liver. Potential complications from the biopsies include bleeding. However, it is 
possible that the study treatment may affect the safety of the operation in some currently 
unforeseen way. I will be closely monitored for any potential problem which may affect the 
operation following the study treatment, and will not undergo the operation until the 
doctors feel that there is no additional risk for me. 
My participation in the study may affect the timing or scheduling of my operation and/or the 
start of my chemotherapy with the implanted pump. It is expected that I will receive the 
operation 1 to 2 weeks after the study treatment, but as described above the operation may 
be further delayed if I experiences any significant side-effects or complications. Once I 
have the operation and the pump is implanted, there will be another delay before the pump 
is used to administer chemotherapy. If I had not participated in the study, the pump is 
usually used one week after the operation. By participating in the study, it is expected that 
the pump will be available for use 2 to 3 weeks after the operation, after the CT or MRI 
scans are performed. 
Risks Associated with Other Study Procedures 
Hepatic vein sampling is a procedure that will be used solely to obtain information for the 
study, by collecting blood from the major vein leaving the liver. It is not part of the hepatic 
angiogram procedure and is unrelated to the evaluation for a hepatic artery infusion pump. 
In this procedure, a catheter will be inserted into a vein in the arm and then guided to the 
hepatic vein by X-ray. Potential complications include infection and bleeding. 
If I do not undergo an operation to place a hepatic artery pump, then a procedure called fine 
needle aspiration will be performed to take small biopsies of my tumor. This commonly 
used procedure may be done as an outpatient. Potential complications include infection and 
bleeding. 
During the course of the study, blood tests will be drawn for the usual tests that are a part 
of my medical care, but in addition I will have other blood tests which are a specific part of 
this study. The additional blood tests do not represent an important amount of blood to be 
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