lost from my body. However, collecting the blood from my veins with a needle will 
involve minor pain at that site. 
Additional Risks 
The study involves a new and investigational drug, ACN53, which has never been given to 
patients prior to this study. The drug has been extensively tested in both small laboratory animals 
and in primates and found to be safe in those animals. However, despite best efforts to ensure 
safety, it is possible that additional risks and/or discomforts which are presently unknown or 
unforeseen may occur, including the possibility of unknown or unforeseen effects or 
complications. 
FINANCIAL RISKS 
There are usually significant costs associated with any cancer treatment, including the treatment 
in this study. However, there will be no charge to me or my insurance carrier for the 
experimental portions of the care of my liver tumor. The investigational drug ACN53 will be 
supplied to me through the doctors at no charge. All other medications, laboratory fees for 
standard tests, doctor, clinic, and hospital costs which are not part of the study treatment may 
be charged to me or to my health insurance carrier. If I participate in the study, these costs will 
be billed by the doctors and the hospital in the usual fashion just as they would if I were not on 
the study. I am advised to discuss these issues in advance with my insurance carrier and with a 
financial counselor. 
BENEFITS 
It is not known if this treatment program will be of any benefit in controlling my disease. 
The benefit I receive from this treatment may be minimal, or I may receive no benefit from 
this treatment at all. My participation may help future patients benefit from the knowledge 
gained through this study. 
ALTERNATIVES 
At the present time I have several options. These are: 
1 . I may choose to receive no specific cancer treatment at this time. I may still be able 
to receive all appropriate supportive medical care, and I may choose to receive some 
form of cancer treatment in the future. 
2 . I may choose to receive another kind of cancer treatment, to be determined by my 
doctors and myself, which may include: 
a. Surgical operation of my abdomen with placement of a hepatic artery 
infusion pump which can later be used to administer chemotherapy to my liver. 
b . Non-surgical placement of a temporary catheter (a thin tube) into the 
region of the Liver which can be used to deliver chemotherapy to my liver. 
c. Intravenous chemotherapy. 
d . Other investigational or experimental forms of cancer treatment. 
3 . I may choose to participate in this research study. 
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Recombinant DNA Research, Volume 20 
