FF Principal Investigator/Program Director (Last, first, middle ): 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants and collaborators. Begin with the principal 
investigator/program director. Photocopy this page for each person. 
NAME POSITION TITLE 
Robert S. Warren, M.D. Associate Professor of Surgery 
EDUCA I ION (Begin with baccalaureate or other initial professional education, such as nursing, and indude postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
Cornell University, Ithaca, NY 
Lawrence University, Appleton, Wisconsin 
Univ. of Minnesota, Minneapolis 
BA 
1971 
Biology 
Physiology 
Grad. School, Univ. of Minnesota, Minneapolis 
Med. School, Univ. of Minnesota, Minneapolis 
MD 
1980 
Cell Biology 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and 
honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. 
Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or 
baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project Include present membership on 
any Federal Government public advisory committee. List in chronological order, the titles, all authors, and complete references to all publications during the 
past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. 
RESEARCH AND PROFESSIONAL EXPERIENCE: 
1980-1983, 1986-1988 
1983- 1986 
1984- 1985 
1988-1994 
1994-present 
Surgery Internship and Residency, University of Minnesota 
Fellowship, Memorial Sloan-Kettering Cancer Center; NY, NY 
Associate Physician, Rockefeller University; NY, NY 
Assistant Professor, Department of Surgery, Univ. of Calif., San Francisco 
Associate Professor, Department of Surgery, Univ. of Calif., San Francisco 
HONORS AND AWARDS: 
1971 BA magna cum laude 
1980 Alpha Omega Alpha Honorary Medical Society 
PUBLICATIONS: 
Warren, RS, Cunningham, WP, Ruben, L, Rothberg, K, and Hooper, AB. Mitochondrial growth during the 
early phase of culture growth in Tetrahymena. J. Cell Biol. 65:448a, 1975. 
Warren, RS, Jeevanandam, M, and Brennan, MF: Protein synthesis in the tumor-influenced hepatocyte. 
Surgery 98:275-281, 1985. 
Warren, RS, Molt, P, Paidas, CN, Jeevanandam, M, and Brennan, MF: Impaired metabolic response to 
endotoxin in obstructive jaundice. Surgery 100:349-3 55, 1986. 
Warren, RS, Jeevanandam, M, and Brennan, MF: Comparison of hepatic protein synthesis in vivo versus 
in vitro in the tumor-bearing rat. J. Surg. Res., 42:43-50, 1987. 
Warren, RS, Starnes, HF, Gabrilove, JL, Oettgen, HF, and Brennan, MF: The acute metabolic effects of 
tumor necrosis factor administration in humans. Arch. Surgery 122:1396-1400, 1987. 
Chapman, PB, Lester, TJ, Casper, ES, Gabrilove, JL, Wong, GY, Kempen, SJ, Gold, PJ, Welt, S, Warren, 
RS, Starnes, HF, Sherwin, SA, Old, LJ, and Oettgen, HF. Clinical pharmacology of recombinant 
human tumor necrosis factor in patients with advanced cancer. J. Clin. Oncol. 5:1942-1951, 1987. 
Starnes, HF, Warren, RS, and Brennan, MF: Protein synthesis by hepatocytes isolated from patients with 
gastrointestinal malignancies. J. Clin. Invest. 80:1384-1390, 1987. 
Warren, RS, Donner, DB, Starnes, HF, and Brennan, MF: Modulation of endogenous hormone action by 
recombinant human tumor necrosis factor. Prot. Nat'l. Acad. Sci. (USA) 84:8619-8622. 1987. 
Starnes, HF, Conti, P, Warren, RS, Jeevanandam, M, and Brennan, MF: Altered peripheral amino acid 
uptake in obstructive jaundice. J. Surg. Res. 42:383-393, 1987. 
Starnes, HF, Warren, RS, Conti, PS, Calvano, S, and Brennan, MF: Redistribution of amino acids in rat 
liver and muscle induced by tumor necrosis factor requires the adrenal response. Surg. Forum 38:41- 
42, 1987. 
Recombinant DNA Research, Volume 20 
[705] 
