Title of Protocol: 
Phase I Study of Adenoviral Vector Delivery of the 
HSV-tk Gene and the Intravenous Administration of 
Ganciclovir in Adults with Malignant Tumors of the 
Central Nervous System 
Institutions: Baylor College of Medicine 
One Baylor Plaza 
Houston, Texas 77030 
The Methodist Hospital 
6565 Fannin Street 
Houston, Texas 77030 
Co-Principal Investigators: Robert G. Grossman, M.D. 
Savio L.C. Woo, Ph.D. 
Co-Investigators: 
H. David Shine, Ph.D. 
J. Clay Goodman, M.D. 
Estuardo Aguilar-Cordova, Ph.D. 
Gayle Rettig, Ph.D. 
Shu-Hsai Chen, Ph.D. 
David Poplack, M.D. 
Marc E. Horowitz, M.D. 
Charles Contant, Ph.D. 
Participating Departments: 
Department of Neurosurgery 
Department of Cell Biology 
Department of Pathology 
Department of Pediatrics 
[710] 
Recombinant DNA Research, Volume 20 
