Fig. 10 Survival study of animals treated with 
either ADV-bgal or ADV-tk and then 50 mg/kg 
of GCV twice daily for 6 days. A Those animals 
treated with ADV-bgal plus GCV died within 22 
days ( ; n = 7); B animals in the first 
experimental group treated with ADV-tk plus 
GCV remain alive after 210 days ( — ;n=5) 
except for one animal that died at 79 days from 
an unknown cause and another that died of 
peritonitis at 131 days. C Animals in the 
second experimental group have remained 
alive up to 174 days expect for 3 that died at 
38, 62, and 151 days after tumor injection from 
suspected peritonitis ( ; n=7). D Animals 
in third experimental group remained alive to 
123 and 137 days when they were perfused for 
histological examination (+) except for one 
animal that died after 98 days from an 
unknown cause ( ; n=4). 
Fig. 11 Gross appearance of sites of viral injection in baboon brains. A. Site of injection 6 
weeks after injection of 3 x 10 10 viral particles (high dose) and no GCV treatment. B. Site of 
injection 6 weeks after injection of 1.5 x 10 9 viral particles and treatment with GCV. 
Recombinant DNA Research, Volume 20 
[737] 
