throughout your body by the blood vessels. In the baboon experiments we did not observe 
any adverse effects from virus leaking out of the brain and infecting other parts of their 
bodies. 
Risk of Cytovene® Therapy: 
Cytovene® has been used extensively in humans to treat a number of infections 
including viral infections of the eye. We will be following the recommended dose for therapy 
that has been used to treat viral infections of the eye. The most commonly observed 
complication in people receiving Cytovene® has been the development of decreased white 
blood cell and platelet counts. This could result in an increased risk of infection and 
bleeding. We will monitor these counts every other day (during Cytovene® treatment) and 
the drug will be discontinued if the white blood count or platelet count drops significantly. 
Discontinuation of the drug results in normalization of the white blood cell and platelet 
numbers. Cytovene® may cause permanent or temporary infertility and may be associated 
with birth defects. Therefore, women of childbearing age should use effective contraception 
during Cytovene® therapy and men should use contraception during and for at least 90 
days following Cytovene® therapy. Cytovene® can cause cancer in animals. There is no 
information available to estimate the risk of this in humans. 
Additional Risks: 
This procedure is new and it is possible that despite our extensive efforts other 
unforeseen problems may occur including the possibility of unknown and possible disabling 
effects or death. 
IV. DURABLE POWER OF ATTORNEY FOR HEALTHCARE 
You have an illness that at some point may impair your ability to think clearly and to 
make decisions. A Durable Power of Attorney for Healthcare is a process by which you 
appoint someone to make decisions about your medical care should you become, and only 
if you become, unable to make these decisions yourself. Such people might include a 
husband, wife, other family member or close friend. It is important that this person know 
your moral, religious and/or personal preferences in research and medical care. The 
Durable Power of Attorney for Healthcare form helps us give you medical care and assures 
that your preferences in research and medical care are respected, if you should be unable 
to give informed consent. A Durable Power of Attorney for Healthcare form can be obtained 
from your attorney or from the admissions office at The Methodist Hospital. 
V. A TENTATIVE AGREEMENT TO AN AUTOPSY 
In case of death during or after your participation in this research study, we ask you 
for a tentative agreement to an autopsy. This will provide us with an opportunity to learn 
more about the effect of our treatment of your tumor. 
Recombinant DNA Research, Volume 20 
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