Principal Invastigator/Progrtm Praetor (Last, first, middle) 
cri FCTED RELEVANT PUBLICATIONS IN REFERRED JOURNALS 
48. Robson, K., Chandra, T., MacGillivray, R., and Woo, S.LC. 1982. Polysome immunoprecipitations of 
phenylalanine hydroxylase mRNA from rat liver and cloning of its cDNA.. PNAS 79:4701-4705. 
Kidd, V.J., Wallace, R.B., Tam, Z.K., Itakura, K., Golbus, M. and Woo, S.LC. 1983. al-antitrypsin deficiency 
detection by direct analysis of the mutation site in the gene. Nature 304:230-234. 
57 . Woo, S.L.C., L'i"' ", A., Chandra, T., Guttler, F. and Robson, K, 1983. Cloned human phenylalanine hydroxyIa<’. 
gene allows prt...’.-. Jirgr.osis and carrier detection of classical phenylketonuria. Nature 306:151-155. 
58. Kidd, V.J., Wallace, R.B., Tam, Z.K., Itakura, K., Golbus, M. and Woo, S.LC. 1984. Prenatal diagnosis of al- 
antitrypsin deficiency by oligonucleotide mapping of the gene. New Enel. J. Med . 310:639-642. 
69. Ledley, F.D., Grenetl, H.E., DiLella, A.G., Kwok, S.C.M. and Woo, S.LC. 1985. Gene transfer and expression of 
human phenylalanine hydroxylase. Science 228:77-79. 
71. Cox, D.W., Woo, S.LC. and Mansfield, T. 1985. DNA restriction fragments associated with al-antitrypsin 
indicate a common origin for deficiency alleles. Science 228:77-79. 
76. Ledley, F.D., Grenelt, H.E., McGinnis-Shelnutt, M. and Woo, S.LC., Id 986. Retroviral mediated gene transfer of 
human phenylalanine hydroxylase into NIH3T3 and hepatoma cells. PNAS 83:409-413. 
82. DiLella, A.G., Marvit, J., Lidsky, A.S., Guttler, F. and Woo, S.LC. 1986. Tight linkage between a splicing 
mutation and a DNA haplotype in phenylketonuria. Nature 322:799-803. 
94. DiLella, A.G., Marvit, J., Brayton, K. and Woo, S.LG 1987. An amino acid substitution in phenylketonuria is in 
linkage disequilibrium with DNA haplotype-2. Nature 327:333-336. 
95. Ledley, F.D., Darlington, GJ., Hahn, T. and Woo, S.LC., 1987. Retroviral gene transfer into primary hepatocytes: 
Implications for genetic therapy of liver-specific functions. PNAS 84:5335-5339 
101. Ledley, F.D., Grenetl, H.E, Bartos, D.P. and Wqo, S.LC 1987. Retroviral mediated transfer and expression of 
human aJpha-l-antilrypsin in cultured cells. Gene 61:113-118. 
141. Armentano, D., Thompson, A.R., Darlington, G. and Woo, S.LC 1990. Expression of human factor IX in rabbit 
hepatocytes by retrovirus-mediated gene transfer: potential for gene therapy of hemophilia B. PNAS 87:6141- 
6145. 
148. Ponder, K.P., Gupta, S., Leland, F., Darlington, G., Finegold, M., DeMayo, J., Ledley, F., Chowdhury, J.R. and 
Woo, S.LC. 1991. Mouse Hepatocytes Migrate to Liver Parenchyma and Function Indefinitely after Intrasplenic 
Transplantation. PNAS 88:1217-1221. 
51. Ponder, K.P., Dunbar, R.P., Wilson, D.R., Darlington, G.J. and Woo, S.LC 1991. Evaluation of Relative 
Promoter Strength in Primary Hepatocytes. Human Gene Therapy 2:41-52. 
156. Kay, M., Baley, P., Rothenberg, S., Leland, F., Fleming, L, Ponder, K.P., Liu, TJ., Finegold, M., Darlington, G., 
Pokomy, W., and Woo, S.LC. 1991 Expression of Human Alpha- 1 -Antitrypsin in Dogs PNAS 89:89-93. 
158. Liu, TJ., Kay, M., Darlington, G. and Woo, S.LC. 1992. Reconstitution of enzymatic acitivity in hepatocytes of 
phenylalanine hydroxylase deficient mice. Som. Cell & Mol. Gen . 18:89-96. 
168. Kay, M., Li, Q.T., Liu, T.J., Leland, F., Toman, G, Finegold, M. and Woo, S.LC. 1992. Hepatic Gene Therapy: 
Persistent Expression of Human Alpha-l-Antitrypsin in Mice after Direct Gene Delivery In Vivo. Human Gene 
Therapy 3:641-647. 
174. Cristiano, R., Smith, L, and Woo, S.LC. 1993. Hepatic Gene Therapy: Adenovirus Enhancement of Receptor 
Mediated Gene Delivery and Expression in Primary Hepatocytes. PNAS 90:2122-2126. 
178. Li, Q.T., Kay, M., Finegold, M., Stralford-Perricaudet, L, and Woo, S.LC. 1993. Assessment of Recombinant 
Adenoviral Vectors for Hepatic Gene Therapy. Human Gene Therapy 4:403-409. 
179. Kay, M., Rothenberg, S., Landen, C., Bellinger, D., Leland, F., Toman, G, Finegold, M., Thompson, A., Read, M. t 
Brinkhous, K. and Woo, S.LG 1993. In Vivo Gene Therapy of Hemophilia B: Sustained Partial Correction of 
Factor IX Deficient Dogs. Science 262:117-119. 
181. Cristiano, R.J., Smith, LC., Kay, M., Brinkley, B. and Woo, S.LC. 1993. Hepatic Gene Therapy: Efficient Gene 
Delivery and Expression in Primary Hepatocytes Utilizing a Conjugated Adenovirus/DNA Complex. PNAS 
90:11548-11552. 
182. Kolodka, T., Finegold., M. and Woo, S.LG, 1993. Hepatic gene therapy: Efficient retroviral mediated gene 
transfer into rat hepatocytes in vivo. Som. Cell & Mol. Gen . 19:5:491-497. 
186. Kay, M., Landen, G, Rothenberg S., Taylor, L, Leland, F., Wiehle, S., Fang, B., Bellinger, D., Finegold, M., 
Thompson, A., Read, M., Brinkhous, K. and Woo, S.LG 1994. In vivo gene therapy: Complete albeit transient 
correction of factor IX deficiency in hemophilia B dogs. PNAS 91:2353-2357. 
187. Chen, S.H., Shine, D., Goodman, G, Grossman, R., and Woo, S.LC. 1994. Gene therapy for brain tumors: 
Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. PNAS 91:3054-3057. 
Recombinant DNA Research, Volume 20 
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