( ,88 ) 
It would be fuperfluous to obferve upon what is 
faid about th zSimarouba, and how far it may remedy 
the Defers of Ipecacuanha> the Trials of it being few, 
not fufficient to determine the Univerfality of its Ufe. 
Far lefs (hall I enquire, whether the IFeft-India Plant 
has any relation to the Macir from the Eaft-lndies, 
mentioned by Pliny though I with Dr. de Jujfieu 
had prepared the Simarouba with Honey , fince the 
great Cures, recorded by Pliny , by the Macir might 
be aflifted by its being prepared in that Way. 
I (hall then proceed, and m ike the foregoing Account 
more perfeQ, and more obvious, better fitted to fix the 
Views of Phyficians, in the Point they are to purfue. 
For thisPurpofe,I (hall give a plain Account of the fe- 
veral Species of a Loofenefs, and in each of them apply 
the different Kind of Remedies employ’d for the Cure 
of them. Thus we fhall perceive the proper Admi- 
niftration for every Loofenefs, and how far any of 
them is left without a Cure. 
The Anatomy of the Guts alone, informs us, that 
the immediate Caufe of every Loofenefs , whether it 
be Symptomatick orEffential, muft either be a quicker 
Conveyance of the common Quantity of concoffedFood, 
and of the Liquors that are commonly mixed with 
it in the Guts . Or the Caufe of a Loofenefs is a 
greater Secretion than ordinary , of a watry Sub - 
fiance from the Blood into the Guts , and brought in- 
to them by the Pancreas, and various other Glands. 
In both which Cafes there muft needs be a larger 
JDifcharge of liquid Excrements, by Stool , than ufual % 
or there muft be a Loofenefs . 
A Loofenefs produced by the firfl: of thefe Caufes, 
admits of great Variety ; both on the Account of the 
different 
* Hifto Natur. lib. xii. 
