_ < ia ) 
red Globules of the Blood , as has been obferved 
before. 
In hot Countries, where large Dofes of Opium are 
taken, the Effects are nearly the fame with what 
we obferve in Drinkers of diftill’d Spirits of fermen- 
ted Liquors $ to wit, a fmall Dofe exhilerates, a greater 
brings on fome Degree of Drunkennefs, or temporary 
Madnefsj this encreas'd will lay to Sleep, and a very 
great Dofe will kill. 
In this Comparifon therefore, may we not juftly 
conclude a Parity in the Caufes, from the Similitude 
of the Effe&s ; though all thefecondary Qualities of 
fuch Caufes, which offer themfelves outwardly to 
our Senfes, be apparently very different ^ thus Gun- 
powder is as much a latent Fire as Brandy, and will 
exert itfelf in that Shape to a far greater Degree than 
it, in equal Circumftances, that is, by the leaft Con- 
tact of Fire j therefore, I fay, that though Brandy 
and Opium {hew no outward Refemblance to our 
Senfes in Smell, Tafte, Colour, Confidence, and fuch 
like fecondary Qualities, no more than Brandy and 
Gun-powder ; yet if in proper and equal Circum- 
ftances, that is, in Contact and Mixture with the 
Blood, they produce the fame, or nearly the fame 
Effects, we may juftly conclude, that there is a la- 
tent Similitude of primary Qualities in their Natures, 
which they make manifeft in proper and equal Cir- 
cumftances, in producing the fame or parallel 
Effects. 
But it has been fliewn above, how, -and in what 
manner Brandy fetters and intangles the animal 
Spirits, and other Fluids of the Blood , uniting them 
to d intimately with the groifer Parts, and thereby 
hin- 
