( 1 $ ) 
hindering their due Secretion for fome time 5 whence 
a Paucity of Spirits, which difcovers itfelf by an 
Inequality and Irregularity of their Diftribution in 
Drunkennefs ; a ftill greater DefeQ: in Dulnefs and 
Drowiinefs ; yet more in Sleep, and a total Suppref- 
fion of their Secretion, as well to the natural and vi- 
tal as to the animal Organs, which is Death, the Ef- 
fect of the greateft Dofes either of fuch diftillM Spi- 
rits or of Opium. 
From what has been faid on this Subject, it feems 
as plain as the Nature of fuch a Phyfical Demon- 
fixation will admit of. 
I. That the univerfal Caufe of Sleep is a Paucity 
of animal Spirits. 
II. That this Defeft will arife from whatever ex« 
haufts, waftes or evaporates them when produced, as 
Labour or Exercife ; or from whatever abforbs them, 
as a great Quantity of crude Chyle, recently and fud- 
denly admitted into the Blood , in the Time of, or 
foon after, a plentiful Meal or whatever can fetter or 
reunite them with the groffer Parts of the Bloody as 
much as Brandy or fpiritous fermented Liquors and 
Opiates . All thefe either by evaporating and wa- 
fting them, or by hindering their Produftion or Se- 
cretion, do bring on that Paucity of Spirits fpoken of, 
and Sleep or fome Degree of Sleepinefs, as a neceffary 
Confequence. 
Yet it will be ftill true upon the fame Foot of 
Reafoning, that where the Blood is extreamly depura- 
ted, and the Secretions and Excretions from it already 
perfectly performed, as in long Faffing the whole Mafs 
of Blood is become only fit for the Secretion of Spi- 
rits j. has no Crudity or Impurity in it, to abforb or 
fetter 
