62 
SUMMARY OF CURRENT RESEARCHES RELATING TO 
Sporozoa of Sarcoma.* * * § — Mr. J. J. Clarke describes certain bodies 
which he finds are constanly present in sarcoma. From their general 
appearance and from their resemblance to the psorosperms of the ureter 
and to the cell-inclusions of carcinoma the author believes them to be 
Sporozoa. They are present in all varieties of sarcoma, and their 
intracellular free and sporing forms are easily recognizable. The 
number of the bodies present is proportionate to the rapidity of growth 
of the neoplasm. 
Sarcoma and Sporozoa. - ) - — Dr. Wedeler describes a case of round- 
celled sarcoma in which Sporozoa were present. The pieces were fixed 
in 5 per cent, sublimate hardened in alcohol and the sections stained 
with hfematoxylin and eosin. The nuclei of the tissue cells are stained 
blue, while the parasite is yellowish. As a rule the parasite is circular, 
of variable size, and nearly always a nucleus is present. Most examples 
are intracellular, but some lie free between the cells. The numbers 
present vary inversely as size, thus when there is only one body in the 
cell it is large and well formed, when numerous they are small. Though 
the predominating shape is circular, many of the parasites are oval, and 
this shape may be due to endogenous fission. 
Crescentic and Flagellated Bodies in Malarial Blood.J — After de- 
scribing the appearances most common in malarial blood, Dr. P. Manson 
discusses the nature of the crescentiform and flagellated bodies and their 
significance. The flagellated body, which is a constant feature of and 
always present in cases of malaria, is evolved either from the crescenti- 
form body or from certain large pigmented intracorpuscular forms. The 
flagellated form is, however, never found immediately after the with- 
drawal of the blood, but requires some minutes (usually not less than 
fifteen) for its development. 
The appearance of the flagella is preceded by changes in the cor- 
puscles and movements of the pigment-granules, after which flagella in 
variable numbers are extruded. The flagella, after exhibiting charac- 
teristic vibratile undulating motions, break away from the central body 
and swim about free in the plasma. 
Though the crescentiform body is not always found in malarial 
blood, it possesses important special characteristics. It may persist in 
the blood for days or weeks after the other intracorpuscular forms have 
disappeared. It is never attacked by phagocytes. It does not undergo 
development within the body, but has been observed to do so after removal. 
From this it is inferred that the crescentiform body is intended to carry 
on the life of the species outside the body, the flagellated organism being 
the first, and the free flagella the second stage of development. Hence 
an extraneous agent to assist the malaria parasite to escape from the 
human body becomes probable. That agent, as in the case of Filaria 
sanguinis nodurna, may be a suctorial insect. 
Plasmodia in Bilious Typhoid.§ — In a small epidemic of bilious 
fever occurring at Alexandria Drs. Schiess and Bitter found in all their 
* Centralbl. f. Bakteriol. u. Parasitenk., xvi. (1894) 809-12 (12 figs.). 
t Tom. cit., pp. 849-53 (1 pi.). 
j Brit. Med. Journ., Dec. 8, 1894, pp. 1306-8 (16 figs.). 
§ Deutsche Med. Wochenschr., 1894, p. 682. See Centralbl. f. Bakteriol. u. 
Parasitenk., xvi. (1894) p. 705. 
