NOTES AND MEMORANDA. 
371 
death take place, when the number of the bacteria is relatively incon- 
siderable ; the vascular ruptures then become of extreme importance ; 
they are found especially in the walls of the heart of the dog. 
It now remains, in order to complete this theory, to examine and 
explain the lesions of the lymphatic system. The following are the 
facts which liave been derived from my experiments : 
Three cases are possible : 
1. The Anthrax was transmitted by inoculation to an animal which 
died without showing vascular ruptures. 
2. The Anthrax was transmitted to the animal by injection direct 
into a vessel. 
3. The Anthrax was transmitted either by inoculation or by intra- 
vascular injection to an animal which in the course of the malady 
showed more or less numerous vascular ruptures. 
In the first case researches made on the fresh or hardened ganglia 
and by means of sections, showed no bacteria except in those situated 
in the course of the lymphatics, proceeding from the inoculated spot, 
where they were found in immense numbers. 
In the second case no ganglion showed the presence of bacteria in 
the sinus; the only ones met with were contained in the blood-vessels 
of the follicles. 
In the third case all the ganglia situated in the course of the 
lymphatics, j>roceeding from the points where the vascular ruptures 
existed, were gorged with bacteria ; the infiltrations in the neighbour- 
hood of the rupture showed heaps of them, formed of long entangled 
filaments, and the ganglia had a quantity of them in their sinus, which 
augmented with the age of the rupture. 
These three cases are easily interpreted ; they are reducible, in 
fact, to one. The mode of action of the bacteria is always the same. 
Take the first (that of inoculation) as a typical case. 
When an animal has been inoculated, from that moment until its 
death it constantly shows the presence of bacteria in one or other 
parts of its economy — not latent bacteria in the state of the germ, but 
entire and articulated, and visible to the microscope. They are 
always found in the connective tissue adjacent to the inoculated spot, 
and their number is greater in proportion as the period of inoculation 
is distant from that of observation. The infiltration or oedema which 
they provoke, is propagated in the direction of the lymj^hatics which 
collect and convey them to the ganglion. They penetrate this organ, 
as do all finely pulverized solid substances, as red-lead injected under 
the skin and tattoo powders ; I have found them in considerable 
numbers (about ten in the field of the microscope), five hours after an 
inoculation has been made, at two centimetres distance from an axillary 
ganglion, in the pulp of this ganglion. Once in a ganglion they mul- 
tiply, produce inflammation, and a more ready discharge of the sub- 
stances inclosed in the lymphatic sinus ; their multiplication by 
elongation is also a mode of progression ; they finally issue forth 
through the efferent vessels and reach the following ganglion, or 
rather the blood-vessels, where they multiply rapidly and where they 
remain. 
