648 
SUMMARY OF CURRENT RESEARCHES RELATING TO 
lation of the parasite within the red corpuscle, while, according to 
Laveran, these forms are almost accidental. (5) Reproduction is 
entirely endoglobular, according to the Italian theory, while Laveran 
describes a sort of budding as well as segmentation. (6) The author 
points out that the Italian theory has the following consistent cycle : — 
(1) Amceboid endoglobular corpuscles at first non-pigmented. (2) 
These afterwards become pigmented and increase in bulk. (3) There 
are now two different paths open to them, they may either sporulate, 
the spores becoming free in the plasma, or they may remain sterile. 
Under these circumstances they may get larger and larger, sometimes 
becoming free in the plasma (spherical flagellated form), sometimes 
remaining within the red corpuscles (crescent-shaped bodies). 
Parasitic Protozoa in Cancerous Tumours.* — Messrs. M. Armand 
Ruffer and H. G. Plimmer find that in carcinomatous tumours of the 
female mamma some of the Protozoa found therein inhabit the nucleus 
as well as the protoplasm of the' cancer-cell. The Protozoon often ap- 
pears as a small body in the nucleus, and then developes gradually until it 
exhibits the characteristics of the full-grown Protozoon. It then consists 
essentially of (1) a central round, oval or slightly irregular nucleus, 
sometimes connected by fine delicate rays with the periphery ; (2) a 
variable amount of surrounding protoplasm almost filling up the capsule ; 
and (3) a double contoured capsule which surrounds the whole. If the 
nucleus of a cancer-cell ever gets rid of the parasites, it appears to 
heal up in a wonderful manner, the details of which have yet to be 
studied. 
Intracellular Parasitism of Cancerous Neoplasms.t — According to 
Dr. J. Soudakewitseh, the cell-inclusions described by him are for the 
most part surrounded by a double contour. Within is found the parasite 
under the most diverse appearances, usually, however, enclosed by a 
homogeneous viscid material. The cell-inclusions appear at times in 
the form of granules irregularly disseminated, having a filamentous 
arrangement. Their staining reactions show the greatest differ- 
ences, for sometimes they are deeply stained with logwood, at other 
times not at all. Very good pictures are produced by safranin staining 
after fixation with Flemming’s fluid. The cell-inclusions are single or 
in accumulations, and scattered throughout the cancerous tissue, but 
especially on the superficial layers. The author thinks that these forms 
cannot be mistaken for cell-nuclei, as they differ therefrom not only in 
their staining relations, but also in their morphological attributes. 
Most of the cell-inclusions were found in cells, only a few were 
free, and usually these cells exhibited karyokinetic nuclei, or were 
hypertrophic, though occasionally their appearance was observed in 
necrotic cells. When the cancer cell is destroyed the enclosed parasite 
is set free, and then evacuates its contents, spores ; these find their 
way into neighbouring cells, or, if into the blood or lymphatic vessels, 
are carried away to colonize new territory, to which process the term 
metastasis should be applied. 
* Journ. of Pathol, and Bacteriol., i. (1893) pp. 395-403 (1 pi.). 
t Ann. Inst. Pasteur, vi. (1892) No. 8. See Centralbl. f. Bakteriol. u. Para- 
sitenk., xiii. (1893) pp. 399-400. 
