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SUMMARY OF CURRENT RESEARCHES RELATING TO 
definite capsule — a discovery that the author considers is confirmatory of 
the coccidial nature of these bodies. 
A round thick- walled cyst was observed within a cell, inside the cyst 
was seen a thin-walled vesicle which in its turn enclosed a thick-walled 
vesicle. 
In the last he easily recognized a grape-like appearance, made up 
of five roundish bodies. The whole cyst was taken to be the resting 
spore cyst of a coccidium, the thin-walled vesicle was supposed to be 
the spore, and the five roundish bodies were germs. 
Pathogenesis of Malaria.* — The views of Dr. Bacelli on malaria 
infection may be summed up as follows. Severe cases of fever of a 
malarial nature occur in which it is absolutely impossible to demonstrate 
in the blood the presence of pathogenic micro-organisms during the first 
days of the disease. Even when found, these organisms may be so few 
in number that it is impossible to maintain the causal connection 
between the quantity of parasite on the one hand, and the severity of 
the fever on the other. Amoebae may exist in the blood in large 
numbers, provided they have not yet attained the stage of spore-forma- 
tion, without exciting fever. The occurrence of the paroxysm may 
be predicted with certainty if within the blood-corpuscles are found 
micro-organisms in condition of fission or of spore-formation. But when 
an attack has taken place, the sporulating and those new forms which 
were the indicators of the paroxysm are no longer to be found in the 
blood-corpuscles. Among those cases in which a paroxysm has been 
artificially induced, some (even of the severest type) have been ob- 
served, wherein no species of pathogenic micro-organisms have been 
detected within the corpuscles. Fatal cases of undoubted malaria have 
been observed wherein the known forms of Haematozoa have not been 
found. The damage which a microbe sets up in the human organism 
may be referred to the “ morphological blood-dyscrasia ” — i. e. to the pro- 
gressive destruction of the red corpuscles from the action of the parasites 
— or to the “ chemical blood-dyscrasia,” i. e. to the presence in the blood 
of spore and fission products. In either of these ways may the 
aetiogeny of malaria infection be explained. The morphological blood- 
dyscrasia goes hand in hand with the metamorphosis of haemoglobin, 
with the circulation of the intact residue of red corpuscles, and with the 
prevention of the change from haemoglobin into oxyhaemoglobin. All 
this may happen without the production of fever. A positive effect may 
be ascribed to the chemical dyscrasia, in which case the blood is infected 
by the spores arising out of the breaking up corpuscles. At the same 
time, the formation of toxic products recurs, and these exert a morbid 
action on the nervous system, and especially on the vaso-motor ganglia. 
* Deutsche Med. Wochenschr., xviii. p. 721. See Centralbl. f. Bakteriol. u. 
Parasitenk., xiv. (1893) pp. 367-8. 
