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the grofleft of all do in the greater Paflages, when 
they promote Stool. 
Hence the Skill of Preparing, and Adminiflring 
of Medicine confifts in proportioning its manifed, and 
known Properties to the Capacity, and Circumdances of 
the Part it is to operate in, and to intend, or remit its 
mechanical Afle&ions, as it is fooner, or later to take 
place in the greater or lefler Veffels. 
Of the fird Clafs there are few to be reduced fmalle- 
nough to go beyond the greater Paflages, and none of 
them are worth the Pains they require, to fit them 
farther than for Diureticks: beftdes, their natural fic- 
nefs to attract, and join with the ferous Part of the 
Blood, whenever they get into that Stage of Motion, 
runs them off by the Kidneys, before they can un- 
dergo Comminution enough to get farther i but if by 
frequent Repetitions of fuch Medicines, and uncom- 
mon Laxity of the Paflages, any thing is paffed into 
the Habit, their groffnefs fouls the delicate drainers, 
which are left for their Expulflon^ and they lodge 
upon the Glands, and Capillaries in fuch manner, as 
induceth Intermittents. which is obfervable in many 
Perfons, after the ufe of Cream of Tartar, the com- 
mon Cathartick Salts, and the purging Waters, efpe- 
cially at the latter end of the Summer, when the 
heat of the preceding Seafbn hath debilitated the So- 
lids, and left them under too great Relaxation, 
Among the refinous Purges, there are many ve- 
ry powerful ones, but where their Operation is defi— 
red in the Vifcera, Blood and remoter Parts, they 
mud be extreamly divided, and this we find Spi- 
rituous Mendruums will do, by taking up the mod 
fubtil Parts only, and carrying them into very fmall 
Paflages, where their Operation is chiefly by Fufion, 
becaufe the foftnefs of fuch Subdances cannot ena- 
ble 
