Smoking and Tobacco Control Monograph No. 7 
Figure 2 
Nicotine content of cigarettes as compared with FTC-determined values 
(regression analysis) 
Note: “Nicotine intake per cigarette (mg)” indicates total amount of nicotine in the length of cigarette 
tobacco rod smoked in the standard FTC smoking machine assay. 
Key: NS = not significant. 
Source: Benowitz et al., 1983b. 
The second method is based on studies of persons smoking one or two 
cigarettes (Benowitz et al., 1994). This method produced an average dose of 
2.3 mg per cigarette, with a range of 0.37 to 3.47 mg. The study paradigm 
was one in which smokers were deprived overnight and given only one or 
two cigarettes to smoke in the morning. These were the only cigarettes 
allowed all day. The unusually high dose per cigarette most likely reflected 
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