Chapter 7 
Table 2 
Studies of nicotine intake compared with machine nicotine yield 
iStudy 
Population 
Nicotine 
Yields (mg) 
Results 
IRickert and Robinson, 
‘ 1981 
84 during routine medical 
exams 
0.25-1 .3 
PCOT vs. Mach-N 
r = 0.08 
I Russell et al., 1980 
330 from smokers’ clinics 
or research volunteers 
0.5-3.5 
PNIC vs. Mach-N 
r = 0.21® 
iBenowitz et al., 1983b 
1 
1 
i 
272 seeking smoking 
cessation therapy 
<0.1-1 .9 
BCOTvs. FTC-N 
r = 0.15 (n = 137) 
r = 0.06 (n = 123) 
1 Ebert et al., 1983 
76 — mix of smoking cessation, 
hospital employees, 
ambulatory patients 
0.1-1.5 
PNIC vs. FTC-N 
r = 0.25® 
j Gori and Lynch, 1 985 
1 
865 recruited from shopping 
malls; 10 or more cigarettes 
per day 
0.1-1.6 
PNIC vs. FTC-N 
r = 0.37® 
PCOT vs. FTC-N 
r = 0.23® 
Benowitz et al., 1986b 
248 seeking smoking 
cessation (1 37 from 
previous study) 
0.1-1.9 
BCOT values similar for 
FTC-N 0.21 to > 1.0 
BCOT 2/3 of others for 
FTC-N < 0.20 
Russell et al., 1986 
392 from smokers’ clinics 
BCOT vs. Mach-N 
r = 0.13® 
BNIC vs. Mach-N 
r = 0.26® 
Rosa etal., 1992 
1 
125 attending military 
medical center 
0.38-1.38 
BCOT vs. Mach-N 
r = 0.30 
1 Coultas et al., 1993 
! 
298 from Hispanic 
household survey 
— 
SCOT vs. FTC-N 
r = 0.12 
! Byrd et al., 1995 
I 
1 
33 volunteers 
0.13-1.3 
Urine N + metabolites 
vs. FTC-N 
N/24hr: r = 0.68® 
N/cig: r = 0.79® 
^ p < 0.05. 
j Key: PCOT = plasma cotinine concentration; Mach-N = smoking-machine-determined nicotine yield; PNIC = plasma 
j nicotine concentration; BOOT = blood cotinine concentration; FTC-N = machine yield by FTC method; 
I BNIC = blood nicotine concentration; SCOT = saliva cotinine concentration; N = nicotine. 
103 
r-aai 
