Smoking and Tobacco Control Monograph No. 7 
the graph, but if you look at the data above .13 and at or below 1.02 FTC 
yield, the correlation is .16. In other words, except for the extremes in your 
own data, there is no relationship. 
DR. DEBETHIZY: Yes, it is interesting to me. 1 think what we have done 
is taken the best available technology, done what Jack Henningfield asked 
people to do, which is to take a look at things using modern techniques, and 
we have done a study that 1 think causes us to stop and think about what 
the previous data have shown. We can manipulate those data to get them 
to look like what the other data look like, or we can take them on their own 
merits, and 1 think that what we need to do is follow this study up with 
further work, and that is why we are doing that, and 1 have encouraged 
Dr. Benowitz to do the same thing. 1 have encouraged the Swedish Tobacco 
Company, which has the capability to do the same thing. 
1 think rather than doing some data selection on this particular study 
we should take it on its own merit. It is a 33-person study. It suggests that 
when smokers can freely do their activities, people consuming lower yielding 
cigarettes absorb less nicotine. Now, it also suggests that there is large 
interindividual variation, and I think lots of people have pointed that out. 
When you do a study like this, you are going to get extremes because 
people smoke cigarettes across a wide range, and I think you have to include 
those people, and I think as we and others fill the data in over time we will 
find out whether this correlation or the slope of this line is as steep as it is 
now or whether it is shallower, and I just think we need to continue to do 
that work. We have worked hard to develop a state-of-the-art technique, 
and I think it has merit. 
DR. SHIFFMAN: I think it has merit, too, and I applaud you for doing it. 
At the same time we ought to be clear on what the data show, and the data 
show that people smoking brands above 1.03 are getting more than people 
smoking brands at about .13 and that in the middle range there is no 
relationship to the FTC yield. 
DR. FREEMAN: Dr. Benowitz, does that answer both of your questions? 
DR. BENOWITZ: Yes. 
DR. FREEMAN: Dr. Rickert? 
DR. RICKERT: In the media recently, the cigarette Eclipse was described, and 
it is obvious from the media description that the cigarette is going to pose 
some challenges for the FTC methodology, in particular because it does not 
burn down to a fixed butt length. J'here are some other challenges that may 
be posed by that cigarette to the ITC methodology, and in particular I am 
wondering about the distribution of nicotine between the gas phase and the 
particulate phase. That is, in the current I'l'C methodology when testing the 
Eclipse cigarette, will the amount of nicotine that is being delivered by that 
cigarette be trapped using the traditional Cambridge Filter method? 
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