Section II 
recommend that a given cigarette should be tested to see what its range of 
possible exposure would be using whatever techniques make sense; is there 
any disagreement with putting that forward? Dr. Hoffmann? 
DR. HOFFMANN: 1 think that Dr. Benowitz' old studies concentrated on 
nicotine, but 1 think when we test on humans and try to see how they 
smoke, we should not limit it to nicotine. There are other carcinogenic 
toxic agents, and 1 think that the work done by Dr. Benowitz on nicotine 
is outstanding, but it is nicotine, and when we deal with cancer, at least, 
that is my area of expertise, there are agents that are just as important. 
DR. FREEMAN: 1 did not understand that you were speaking only of 
nicotine. Were you not speaking of tar and the three things that are 
mentioned? 
DR. BENOWITZ: Yes, in terms of the machine testing I was certainly 
speaking of all. In terms of human bioavailability testing, 1 think as 
Dr. Hoffmann says, if we have tools to measure tar exposure, we definitely 
should do that. Right now the only practical tools for large-scale studies 
are nicotine and CO, but when we get tar measurement tools where we can 
do it on hundreds of people, that should be included. 
DR. TOWNSEND: If 1 could respond, my reaction to your proposal is that 
if we provide to the consumer an FTC number and a maximum deliverable 
number by hole blocking and a more intense puffing regimen, which 1 
believe is your proposal, then from what I know about cigarette design those 
two are going to very closely parallel each other, and the ranking of cigarettes 
will be largely preserved. My question then is, does that provide additional 
and useful information to the consumer? 
DR. BENOWITZ: I would like to respond to that. 1 do not believe that 
the ranking will be preserved. If you have the old-style cigarettes that are 
nonfilter cigarettes, no matter what you do, the ranking is going to be 
preserved, but if you are comparing a nonfilter cigarette and then a cigarette 
that has extensive ventilation and you block holes, you might see one 
surpass the other. I just do not believe that when you are dealing with a 
cigarette that has 90 percent ventilation in a standard test and people have 
the possibility of reducing that to zero percent ventilation, and you are 
comparing that to cigarettes with no ventilating filters, the ranking will 
be preserved. 
DR. TOWNSEND: As a cigarette designer, 1 believe that it will be largely 
preserved, and I guess what 1 am hearing you say is that this is your 
suspicion, but 1 guess my question, is do you have data that support that, 
and 1 guess the obvious direction 1 am going in with this question is, should 
we collect data to see whether the ranking is largely preserved to convince 
you? 
DR. FREEMAN: I think we have a question over here. 
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