MINUTES OF MEETING - March 6-7 
28 
Dr. Walters said the visit had been arranged by Dr. Barkley at 
Dr. Fredrickson's request. He said the visit had two goals : (1) to 
examine the containment facilities at Lilly, and (2) to gather information 
that would be helpful in revising the draft large-scale standards. 
Dr. Walters said the visit consisted of (1) a discussion of review, moni- 
toring, and health surveillance procedures, (2) an inspection of several 
laboratories and a factory facility, and (3) a discussion of the November 14, 
1979, draft large-scale standards. 
Dr. Walters reported that the group had seen fermentors of three different 
sizes: 10-liters, 150-liters and fermentors in the range of 2,000 to 
50,000 gallons. He said several potential containment problems must be 
confronted when dealing with standard fermentors. These include: (1) 
leakage or spills of inocula introduced or of samples removed fran the 
fermentor for testing, (2) exhausting of aerosols produced during fermen- 
tation, (3) leakage of aerosols around the fermentor agitator blade shaft, 
and (4) the vulnerability of the pipe and valve at the bottom of the 
vessel . 
Mr. Thornton said he wished to add three additional points to Dr. Walters' 
report. He said Eli Lilly engineers told the group that: (1) most' of the 
supply lines to the facility which contains two 150-liter fermentors were 
independent of supply lines to the rest of the plant with the exception 
of electric power and steam lines which were held in common with the rest 
of the plant, (2) a negative pressure differential within the two 150-liter 
fermentors ensured that any leakage around the shafts would be siphoned 
into the fermentors and (3) there were no drain valves at the bottom of 
these 150-liter units. 
Dr. Barkley agreed with the reports of Dr. Walters and Mr. Thornton, and 
said the group had concluded that the engineering designs employed were 
appropriate. 
Dr. Parkinson asked if the plant was organized. Dr. Johnson replied that 
the plant is not unionized. Dr. Parkinson asked if members of the group 
had had the opportunity to speak with workers in the absence of manage- 
ment. Dr. McKinney said he had spoken with two or three people in the 
absence of management and was very satisfied with their responses to his 
questions. Dr. Baltimore asked whether the group had spoken with produc- 
tion line workers not necessarily using recombinant methods. Mr. Thornton 
replied that the group had had the opportunity, but he did not know if any- 
one had availed themselves of it. Dr. Parkinson asked whether workers 
are represented on the Health and Safety Committee in the plant, and if 
the group had spoken with these members. Dr. Johnson replied that there 
are worker representatives on the Committee, and Dr. McKinney said that 
the visitors had not spoken with them. Dr. Mason asked about the Eli 
Lilly employee health and medical surveillance program. Dr. Walters, 
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