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Federal Register / Vol. 45, No. 227 / Friday, November 21, 1980 / Notices 
and Arachnia propionica) 
Blastomyces dermatitidis 
Cryptococcus neoformans 
Paracoccidioides brasiliensis 
3. Parasitic Agents 
Endamoeba histolytica 
Leisbmania sp. 
Naegleria gruberi 
Toxoplasma gondii 
Toxocara cam's 
Trichinella spiralis 
Trypanosoma cruzi 
4. Viral, Rickettsial, and Chlamydial 
Agents 
Adenoviruses — human — all types 
Cache Valley virus 
Coxsackie A and B viruses 
Cytomegaloviruses 
Echoviruses — all types 
Encephalomyocarditis virus (EMC) 
Flanders virus 
Hart Park virus 
Hepatitis-associated antigen material 
Herpes viruses — except Herpesvirus 
simiae (Monkey B virus) which is in 
Class 4 
Corona viruses 
Influenza viruses — all types except A/ 
PR8/34, which is in Class 1 
Langat virus 
Lymphogranuloma venereum agent 
Measles virus 
Mumps virus 
Parainfluenza virus — all types except 
Parainfluenza virus 3, SF4 strain, 
which is in Class 1 
Polioviruses — all types, wild and 
attenuated 
Poxviruses — all types except 
Alastrim, Smallpox, Monkey pox, 
and Whitepox, which depending on 
experiments, are in Class 3 or Class 
4 
Rabies virus — all strains -except 
Rabies street virus, which should be 
classified in Class 3 when 
inoculated into carnivores 
Reo viruses — all types 
Respiratory syncytial virus 
Rhinoviruses — all types 
Rubella virus 
Simian viruses — all types except 
Herpesvirus simiae (Monkey B 
virus) and Marburg virus, which are 
in Class 4 
Sindbis virus 
Tensaw virus 
Turlock virus 
Vaccinia virus 
Varicella virus 
Vole rickettsia 
Yellow fever virus, 17D vaccine strain 
C. Class 3 Agents 
1. Bacterial Agents 
Actinobacillus mallei * 
Bartonella — all species 
Brucella — all species 
Francisella tularensis 
Mycobacterium avium, M. bo vis, M. 
tuberculosis 
Pasteurella multocide type B 
(“buffalo" and other foreign virulent 
strains *) 
Pseudomonas pseudomallei * 
Yersenia pestis 
2. Fungal Agents 
Coccidioides immitis 
Histoplasma capsulatum 
Histoplasma capsulatum var. duboisii 
3. Parasitic Agents 
Schistosoma mansoni 
4. Viral, Rickettsial, and Chlamydial 
Agents 
* ' * Alastrim , Smallpox, Monkey pox, 
and Whitepox, when used in vitro 
Arboviruses — all strains except those 
in Class 2 and 4 (Arboviruses 
indigenous to the United States are 
in Class 3, except those listed in 
Class 2. West Nile and Semliki 
Forest viruses may be classified up 
or down, depending on the 
conditions of use and geographical 
location of the laboratory.) 
Dengue virus, when used for 
transmission or animal inoculation 
experiments 
Lymphocytic choriomeningitis virus 
(LCM) 
Psittacosis-Ornithosis-Trachoma 
group of agents 
Rabies street virus, when used in 
inoculations of carnivores (See 
Class 2) 
Rickettsia — all species except Vole 
rickettsia when used for 
transmission or animal inoculation 
experiments . 
Vesicular stomatitis virus * 
Yellow fever virus — wild, when used 
in vitro 
D. Class 4 Agents 
1. Bacterial Agents: None 
2. Fungal Agents: None 
3. Parasitic Agents: None 
4. Viral, Rickettsial, and Chlamydial 
Agents 
*** Alastrim, Smallpox, Monkey pox, 
and Whitepox, when used for 
transmission or animal inoculation 
experiments 
Hemorrhagic fever agents, including 
Crimean hemorrhagic fever. 
(Congo), Junin, and Machupo 
viruses, and others as yet undefined 
Herpesvirus simiae (Monkey B virus) 
Lassa virus 
Marburg virus 
Tick-borne encephalitis virus 
complex, including Russian spring- 
summer encephalitis, Kyasanur 
forest disease, Omsk hemorrhagic 
fever, and Central European 
encephalitis viruses 
Venezuelan equine encephalitis virus, 
epidemic strains, when used for 
transmission or animal inoculation 
experiments 
Yellow fever virus — wild, when used 
for transmission or animal 
inoculation experiments 
II. Classification of Oncogenic Viruses 
on the Basis of Potential Hazard [ 2 ] 
A. Low-Risk Oncogenic Viruses 
Rous Sarcoma 
SV-10 
CELO 
Ad7-SV40 
Polyoma 
Bovine papilloma 
Rat mammary tumor 
Avian Leukosis 
Murine Leukemia 
Murine Sarcoma 
Mouse mammary tumor 
Rat Leukemia 
Hamster Leukemia 
Bovine Leukemia 
Dog Sarcoma 
Mason-Pfizer Monkey Virus 
Marek’s 
Guinea Pig Herpes 
Lucke (Frog) 
Adenovirus 
Shope Fibroma 
Shope Papilloma 
B. Moderate-Risk Oncogenic Viruses 
Ad2-SV40 
FeLV 
HV Saimiri 
EBV 
SSV-1 
GaLV 
HV ateles 
Yaba 
FeSV 
III. Animal Pathogens (3) 
A. Animal disease organisms which 
are forbidden entry into the United 
States by Law (CDC Class 5 agents) 
1. Foot and mouth disease virus 
B. Animal disease organisms and 
vectors which are forbidden entry into 
the United States by USDA Policy (CDC 
Class 5 Agents) 
African horse sickness virus 
African swine fever virus 
Besnoitia besnoiti 
Borna disease virus 
Bovine infectious petechial fever 
Camel pox virus 
Ephemeral fever virus 
Fowl plague virus 
Goat pox virus 
Hogcholera virus 
Louping ill virus 
Lumpy skin disease virus 
Nairobi sheep disease virus 
Newcastle disease virus (Asiatic 
strains) 
Mycoplasma mycoides (contagious 
bovine pleuropneumonia) 
Mycoplasma agalactiae (contagious 
[25] 
