16 
MINUTES OF MEETING - June 5-6 
proposal was adequate, as an intact 3' end was necessary for polymerase 
recognition. Dr. Campbell pointed out that PIADC-Genentech, Inc., had 
responded to the concerns voiced by RAC members at the December 6-7, 
1979 meeting by providing extensive molecular characterization cf the 
material to be .shipped. He said he had no difficulty in approving the 
application as it stands. Dr. Baltimore concurred. 
The negative results of the infectivity assays were discussed. Dr. Callis 
indicated that such tests would be made on all vials containing clones 
of the FMD genome to be transported off Plum Island. He said the USEA 
Vectors Committee would evaiuate the safety of all materials before grant- 
ing permission to ship. 
Dr. Krimsky noted that some sequencing had been performed at Plum Island. 
He asked why Stage II could not be performed at Plum Island. Dr. Ross 
of Genentech, Inc., said that the sequencing could be done on Plum Island, 
but only at cons iderable time and expense. 
Dr. Baltimore moved approval of the PIADC-Genentech, Inc., proposal as 
submitted . He s: id his motion would not require that clone pCT 196 be 
restricted to Plum Island. By a vote of twelve in favor, two opposed, 
and four abstentions, the RAC approved the PIADC-Genentech, Inc., pro- 
posal to ship the 17 requested clones frem the Plum Island Animal Disease 
Center to the Genentech, Inc., facilities in California. 
Dr. Talbot said that at the December 6-7, 1979 meeting the RAC recommended 
PI + EKl containment conditions for experiments performed at the Genen- 
tech, Inc., facilities with the clones to be sent from PIADC. He said 
Dr. Fredrickson deferred approval of these containment conditions at 
that time until data on Stage I and infectivity assays could be evaluated 
by the RAC. Dr. Campbell moved that Genentech, Inc., be allowed to work 
with the clones under PI + EKl conditions. Dr. Goldstein asked what 
containment conditions were employed at Plum Island. Dr. Callis responded 
that containment on Plum Island is between P3 and P4. 
Dr. Setlow called the question and the RAC recommended by a vote of eleven 
in favor, one opposed, and five abstentions that containment levels for 
work with the clones at the Genentech, Inc., facilities be set at PI + 
EKl. 
VII. PROPOSAL TO AMEND SECTION III-O OF THE GUIDELINES TO PERMIT USE OF Ff 
PHAGES 
— 
Dr. Campbell related the history of the proposal (tab 865, 866, 867, 868, 
881/1) to include Ff phages under Section III-O of the Guidelines. He 
said that Dr. Fredrickson, when the January 1980 Guidelines were promul- 
gated, raised the question of whether filamentous F-specific phages should 
be included under Section III-O. As Section III-O precludes the use of 
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