32 
MINUTES OF MEETING - June 5-6 
Dr. Campbell discussed the sentence of the proposed text of Section 
III-O which reads: 
"An exception which does require prior review and approval by the IBC 
is any experiment in which there is a deliberate attempt to have the 
E. ooli K-12 or Saccharornyces cer evisiae efficiently express as a 
protein product, the information carried in any gene derived from a 
eukaryotic organism or from any virus or viroid which infects a 
eukaryotic organism." 
He questioned whether the statement would apply to self-cloning experi- 
ments involving Saccharornyces cerevisiae . He suggested the reference to 
Saccharcmyces cerevisiae in this sentence be struck. 
Dr. Gottesman asked if there were any product, produced by a recombinant- 
containing Saccharcmyces cerevisiae host-vector system, which might have 
an ecologically unfavorable effect. Dr. Fink said that Saccharornyces 
cerevisiae , unlike Escherichia coli, exports very few protein products. 
He felt it would be difficult to engineer Saccharcmyces cerevisiae to 
export polypeptide products. Dr. Novick asked if Saccharcmyces cerevisiae 
participates in genetic exchanges with organisms other than the appropriate 
Saccharornyces cerevisiae mating type. Dr. Fink replied that it did not. 
He added that mating with the mating type was difficult to affect even 
in the laboratory situation. 
Dr. Goldstein asked if Saccharcmyces cerevisiae can be engineered to 
express eukaryotic genesl Dr. Baltimore said that while Saccharornyces 
cerevisiae will not recognize and automatically express eukaryotic genes , 
the system can probably be engineered to do so. 
Dr. Walters moved to amend the proposed language by deleting the words 
"or Saccharcmyces cerevisiae " from the sentence beginning "An exception 
however...." The RAC voted in favor of the motion by a vote of fifteen 
in favor, one opposed, and three abstentions. 
Dr. Broadbent's motion to adopt 881/4 with the modifications of the 
previous motion was accepted by the RAC by a vote of fourteen in favor, 
two opposed, and two abstentions. 
i 
XXII. REQUEST FOR AN EXCEPTICN TO A PROHIBITION TO FIELD TEST CORN GENES IN CORN 
Dr. Brill introduced the request (tab 889, 881/10) of Dr. Ftonald Davis 
of Stanford Medical Center to field test com plants (Zea mays) which have 
been transformed by com DNA or modified com sequences cloned in Escher- 
ichia coli or Saccharcmyces cerevisiae host-vector systems. Dr. Brill 
noted that this request requires an exception to Section I-D-4 which 
prohibits deliberate release into the environment of any organism contain- 
ing recombinant DNA. Dr. Brill said he could not envisage any danger to 
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