25 
Dr. Pinon suggested that P2 containment is adequate. He said Candida 
does not produce toxins; in addition it is non-invasive. Candida 
albicans inhabits mucosal membranes, and is considered a normal ccmpo- 
nent of the microflora. Anywhere from 25 to 100% of the population, 
carry Candida . 
Dr. Novick pointed out that Candida can cause disease in individuals 
receiving broad spectrum antibiotics. Dr. Gottesman said this is 
essentially a return to host of origin experiment, and felt the rele- 
vant question is whether the cerevisiae DNA introduced into Candida 
might contribute to Candida pathogenicity. 
Dr. Pinon moved that the experiments proposed by Drs. Magee and Chaffin 
be permitted at the P2 level of containment. By a vote of fourteen in 
favor, one opposed , and three abstentions, the RAC approved the motion. 
XXIII. INSTITUTIONAL BIOSAFETY COMMITTEE (IBC) SURVEY (Continued) 
Dr. Novick requested an opportunity briefly to address the RAC concerning 
the proposed NIAID evaluation of IBC functions which had been discussed 
earlier in the meeting (Section IV). He said he vould like the RAC to 
go on record as requesting that the RFP being developed include the 
following : 
(1) An evaluation of MUAs or registration documents submitted to IBCs 
for compliance with the Guidelines, and 
(2) An inquiry of how often physical facilities are inspected by IBCs, 
and the results of the inspections. 
Dr. Goldstein supported Dr. Novick' s proposal; he said Dr. Dutton showed 
the performance of individual IBCs is highly variable. Dr. Gottesman 
objected to an evaluation of every registration document; she and Dr. Berns 
thought a sampling procedure might be more appropriate. Dr. Krimsky said 
that practices for social science research usually involved random sampling 
He favored telling the contractor what was to be evaluated, and leaving 
it to the contractor to use the state of the art of evaluation research 
to accomplish the task. 
It was agreed that Dr. Nutter will be asked to discuss the draft RFP with 
the RAC at its January 1981 meeting, prior to the RFP being issued. 
XXIV. DISCUSSION OF INCIDENT AT UNIVERSITY OF CALIFORNIA, SAN DIEGO 
Dr. Goldstein wished to discuss the recent events at the University of 
California, San Diego (UCSD) concerning an apparent infraction of the 
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