2 
VII-A-1. Physical Containment Level For PI and P2 Experiments . 
The P2-LS level of physical containment is required for large-scale research 
or production of organisms requiring either PI or P2 containment at the labo- 
ratory scale. 
VII-A-2. Physical Containment Level For P3 Experiments . The P3-LS 
level of physical containment is required for large-scale research or pro- 
duction of organisms requiring P3 containment at the laboratory scale. 
VII-A-3. Physical Containment Level For P4 Experiments . 
No provisions are made for large-scale research or production requiring P4 
containment. If necessary, these requirements will be established on an 
individual case basis. 
VII-B . P2-LS Level . 
VII-B-1. Laboratory Practices . 
VII-B-l-a. Only persons who have a need and who have been advised of 
the nature of the work shall enter the production area. 
VII-B-l-b. The universal biohazard sign shall be posted on all equipment 
used to process or store organisms containing recombinant DNA molecules, and 
on all access doors to the production area during the period when any work 
involving the organisms is in progress. This includes periods when equip- 
ment contaminated with the organisms is undergoing sterilization. 
VII-B-l-c. The production area shall be kept neat and clean. 
VII-b-1-d. Eating, drinking, smoking, and the storage of food are 
prohibited in the production area. 
VII-b-1-e. An insect and rodent control program shall be maintained. 
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