10 
VII-C-2-b- (2) . Be designed, fabricated, and installed in a manner 
* which facilitates observation during operation to assure the integrity 
of containment. 
VII-C-2-b- (3) . Be designed and fabricated in a manner which provides 
for sterilization of surfaces exposed to organisms containing recombinant 
DNA molecules prior to exposure of these surfaces to the environment. 
VII-C-2-b- (4) . Be designed, fabricated, and installed in a manner which 
I 
facilitates disassembly, cleaning, and maintenance to assure integrity of 
i 
the containment features of the unit. 
VII-C-2-b- (5) . Have all connected utility services protected against 
contamination. 
VII-C-2-b- (6) . Be tested for integrity of the containment features using 
a non-debilitated strain of the species of the host organisms to be employed 
in production. Testing shall be accomplished prior to the initial production 
of organisms containing recombinant DNA molecules, and following modification 
or replacement of essential containment features. Procedures and methods 
used in the testing shall be appropriate for the equipment design and for 
recovery and demonstration of the test organisms. 
VII-C-2-b- (7) . Be permanently identified. This identification shall 
be used in all records reflecting testing, operation and maintenance and 
in all documentation relating to use of this equipment for the production 
of organisms containing recombinant DNA molecules. 
[239] 
