12 
VII-C-3-i. Floor drains serving a curbed or similar area shall be 
sealed during periods when production is in progress. 
*VII-C-3-j . The production area shall have a ventilation system that 
is capable of controlling air movement. The movement of air shall be 
from areas of lower contamination potential to areas of higher contami- 
nation potential. If the ventilation system provides positive pressure 
supply air, the system shall operate in a manner that prevents the 
reversal of the direction of air movement or shall be equipped with an 
alarm that would be actuated in the event that reversal in the direction 
of'air movement were to occur. The exhaust air from the production area 
shall not be recirculated to other areas of the building. The exhaust 
air from the production area may be discharged to the outdoors without 
filtration or other means for effectively reducing an accidental aerosol 
burden provided that it can be dispersed clear of occupied buildings and 
air intakes. 
*VII-C-3-k. The exhaust air from biological safety cabinets and other 
containment units, as well as exhaust gases from production equipment shall 
be treated by a passage through a HEPA filter prior to discharge to the 
outdoors. Each air treatment device shall be served by an individual exhaust 
blower and shall be operated so as to avoid any interference with the air 
balance of the production area. 
*Not required for P2-LS. 
[241] 
