Page 3 - Dr. William J. Gartland 
c. Direct personnel monitoring for host-vector organisms, and if 
colonization has occured, further testing for the expression 
of the relevant gene product may be appropriate. 
d. Occupational and medical histories which should include a 
determination of existing factors which might place certain 
workers at increased risk. 
The NIH Laboratory Safety Monograph discusses various possible components 
of a health surveillance and work practices program. This monograph is not 
mentioned in Part VII. It most certainly should form a basis for 
development of work in this area and be referenced where appropriate in Part 
Since work with recombinant DNA molecules is relatively recent, and as 
the host-vector organisms and genome of interest differ between protocols, 
it should be recognized that effective monitoring can present unique 
problems and research in this area is essential and urgently needed. 
Although the introductory paragraph to the draft of Part VII states "all 
provisions of the NIH Guidelines shall apply to large-scale research and 
production activities", critical areas such those commented on above 
should be addressed in Part VII. 
VII 
Seth Pauker 
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