ROCHE INSTITUTE OF MOLECULAR BIOLOGY 
Nutley, New Jersey 07110 
September 11, 1980 
Dr. William Gartland 
Office of Recombinant DNA 
National Institutes of Health 
Bethesda, Md. 20205 
Dear Bill: 
I am writing in support of Dr. Maxine Singer's proposed 
changes in registration requirements for recombinant DNA 
experiments as published in the Federal Register, Vol. 45, 
August 21, 1980 (Item #8). 
These changes delegate primary responsibility to the 
Institution and the investigator as is reasonable and 
appropriate. 
In addition, the proposed changes in administrative 
requirements should tend to re-establish the "Guidelines" as 
guidelines and not regulations, a move in keeping with their 
original intent. 
Yours truly 
X* M. Skalka, Ph.D. 
Department of Cell Biology 
AMS: pep 
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