Page 17 of Attachment H 
Features of Contained Fermentor 
Eli Lilly 2,000 Liter Fermentor 
Second 
Back Up 
Sterile Filter 
Exhaust Gas 
Filter System (1) 
Primary 
Sterile 
Filter 
Compressed Air 
Inlet 
Other Features 
(6) Collection of 
Contaminated 
Condensate and 
Sterilization before 
Release 
D 
D 
Special Double Mechanical 
Seal with Sterile Fluid Purge 
(2) and Loss of Pressure Alarm 
Dip Tube 
Harvest & Fill 
Line (3) 
a 
Stainless Steel 
Sterilizable 
Sampler (4) 
Cooling Jacket 
Agitator 
(7) System Validation 
before Operation 
(8) Monitoring Program 
(9) Operation with 
Detailed Protocol 
Air Sparger 
[ 453 ] 
