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TABLE I 
L- ASPARAGINASE - TOXICITY AND SIDE EFFECTS 
ENZYME per se 
(Asparaginase/Glutaminase ) 
PANCREATITIS 
HEPATOTOXICITY 
(abnormal liver function, 
fatty liver) 
RENAL DYSFUNCTION 
ABNOFMAL CLOTTING 
CNS 
(Depression, lethargy) 
WEIGHT LOSS 
HYPERSENSITIVITY 
(Urticaria, rash, allergy 
skin test reactivity, 
anaphylactoid reaction) 
BACTERIAL CONTAMINANTS 
(e.g.; Endotoxin) 
CHILLS, FEVER 
NAUSEA, VOMITING, ANOREXIA 
HYPERSENSITIVITY 
(Urricana, rash, allergy, 
anaphylactoid reaction) 
HEPATOTOXICITY? 
WEIGHT LOSS? 
