Page 5 of Attachment B 
- process operations with attendant potentials for worker exposure 
- engineering controls (e.g. physical containment design, venti- 
lation, exhaust gas filtration, waste product controls, etc.) 
- validation procedures (e.g. of sterilization, physical contain- 
ment, and process termination) 
- work practices 
- emergency and accident procedures 
- medical surveillance 
- environmental monitoring 
- numbers of exposed workers 
- employee training and education 
This survey of Eli Lilly and Company in Indianapolis was conducted as one 
of a series of initial walk through surveys of firms utilizing recombinant 
DNA techniques in research or production processes. 
DESCRIPTION OF THE FACILITY 
Eli Lilly and Company, with multiple manufacturing sites in the United 
States and abroad, has its headquarters and many of its research and 
manufacturing operations in Indianapolis, Indiana. The company was 
founded in 1876 in downtown Indianapolis. Divisions of pharmaceuticals, 
agricultural products, cosmetics, electronic medical instruments, cardiac 
pacemakers, and research make up the corporate structure. 
Eli Lilly's vast experience in the fermentation industry recently has 
been applied to the research and development of recombinant DNA technology. 
This is exemplified by the sophisticated equipment and systems used in 
Lilly's recombinant DNA processes. Eli Lilly is conducting its research 
and developing production under voluntary compliance with the National 
Institutes of Health (N I H ) Guidelines for Recombinant DNA Research. 
At the time of this survey, genetic engineering research was conducted in 
building 28, 731 S. Alabama St. and building 328, 1200 Kentucky Avenue. 
The main production development efforts are ongoing at the 1200 Kentucky 
Avenue location which houses various P-2, P-3, and P-1 containment level 
1 aborator ies . 
DESCRIPTION OF THE WORKPLACE 
The Indianapolis facilities employ approximately 6,000 persons of whom 
about 4,200 are engaged in direct production of pharmaceutical products. 
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