Page 3 of Attachment D 
DESCRIPTION OF THE WORKFORCE 
Cetus currently employs approximately 230 persons of which about 200 are 
involved with research and process development. Approximately 75% of 
this workforce have at least bachelors degrees and 50 individuals have 
Ph.D.'s. Because of the nature of the work, the typical employee hired 
by Cetus will be highly educated. The pilot scale setting will require 
Very few, if any, line operators. 
No structured work schedule exists for employees; most work is conducted 
during flexible daytime hours. 
DESCRIPTION OF THE PROCESS 
Process development for the production of insulin, interferon, ethanol, 
and ethylene glycol is now underway. Development of fermentation, extrac- 
tion, and purification techniques axe also being conducted. Production 
processes utilising recombinant DNA will vary depending on the nature of 
the product desired and the steps required to achieve the product. General 
"process descriptions for specific products were not yet available partly 
due to the status of the projects. 
Cetus's fermentation processes are conducted in 10 liter or less capa- 
cities. Fermentation capacities larger than 10 liters will not likely 
be employed in process research or pilot scale development and therefore, 
under the current voluntary system, Cetus will not need to submit their 
project plans to the National Institute of Health Recombinant DNA Advisory 
Committee for review. Cetus plans to stay at the lab scale or pilot scale 
level for their research projects. 
The directors of the company will not approve risk assessment experiments 
for in-house project benefit until NIH outlines criteria for such experi- 
ments. The company feels that risk assessments, now by the private sector. 
Could be deemed self-serving and a compromise to research. 
DESCRIPTION OF INDUSTRIAL HYGIENE, 
SAFETY AND MEDICAL PROGRAMS 
. Industrial Hygiene 
This company has no industrial hygienist on staff. Environmental monitor- 
ing has not been conducted in the laboratories or research areas. 
Safety and Health 
The company has a formal safety program that consists of written procedures 
for good laboratory practices. The Safety and Operations Manual for the 
Cetus Corporation P-3 facility is contained in Appendix 1. 
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