Page 6 of Attachment D 
Maintenance of equipment, of systems, or in the laboratories takes place 
only after clearance from a supervisor has been obtained. 
Personnel working in the P-3 laboratory are responsible for the cleanliness 
of the area. Personnel in other laboratory areas are also responsible for 
the general cleanliness of their respective laboratory, but a janitorial 
service cleans the floors and removes the trash. 
Detailed requirements for work practices in the P-3 laboratory can be 
found in Appendix 1. 
Emergency and Accident Procedures 
Safety precautions and plans for emergencies, such as laboratory accidents, 
axe outlined for' each laboratory containment level and research application. 
CONCLUSIONS 
General experience has demonstrated that safe conduct of research, or 
production processes, involving hazardous entities is dependent on good 
vork practices, availability and use of effective control technology, and 
effective management. Microbiological research requires containment fea- 
tures sufficient enough not only to exclude entry of contaminants into, • 
•but also prohibit escape of organisms from the system. Thus, attention to 
exposure control must receive equal emphasis as process integrity and pro- 
■duction development. Safety and health, medical, and emergency programs 
Heed to be implemented and managed with the same degree of attention that 
the scientific production programs receive. It is evident that Cetus 
recognized the importance of safety and health programs and implemented 
these early in the corporate development. Cetus is conducting its research 
end development of recombinant DMA in a well-conceived and adequately de- 
signed work environment. 
RECOMMENDATIONS 
The medical program should consist of. pre- employment and annual physical 
exam inations in order that employees may be' monitored for abnormal health 
effects. Immunizations should be considered for employees working with 
known pathogens. Employee health records should be maintained and include 
notes on all illness, operations, physical disorders, therapeutic medi- 
cations, and accidental exposures. 
A Xegistry of all workers employed with recombinant DNA techniques should 
be established and maintained for future reference to determine any abnormal 
aedical problems, or unusual occurances, that night be attributable to 
Occupation. NIQSH has had considerable experience in designing and main- 
taining such worker registries and can, thus, provide assistance in design, 
implementation , and logistical requirements. The comparability of individual 
company registries is desirable for optimum and successful surveillance on 
industrial wide basis. 
6 
[ 561 ] 
