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Attachment III - Page 2 
2.a.(2) Revise--"adequate" vague, and frequency uncertain at 
first . 
2.c. Request results from similar human studies reports here 
and abroad, with results. 
2.c.(l)(c) "Tumors" for "malignancy" and relocate to I.B.2.c.(l) 
Miller 
2.c.(l)(c) Failure of retroviruses to exhibit oncogenicity or 
other pathogenicity in lab tests no guarantee that 
they will not become novel human pathogens. 
Goldberg 
2.c.(l)(d) Delete "specifically germline cells." How about 
"the specificity of transformation or other effects 
on the target cells?" 
2.c.(l)(e) Clarify: "Describe animal experiments completed or 
in progress employing protocols similar to that 
proposed. " 
Miller 
2.c.(l)(e) Should not require prior primate testing in urgent 
cases . 
Horowitz 
3. Selection of subjects criteria belong here vs. I.C. 
Ho^ovTitz 
M / / / is 
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